The Effects of Teneligliptin on Lipid Profile: A Prospective Study for Comparison of Biomarkers Before and After a Meal

IF 0.6 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Endocrinology and Metabolism Pub Date : 2020-08-25 DOI:10.14740/jem679

O. Tomonaga, Masaki Kobayashi, Ryoma Tagawa, Y. Higami

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引用次数: 1

Abstract

Background: In the treatment of diabetes mellitus, it is important to prevent dyslipidemia, which is one of the complications. However, no study has examined the long-term effects of teneligliptin on the blood parameters of apolipoprotein B (apoB) after a meal in patients with type 2 diabetes. Methods: The effects of teneligliptin on blood glucose and lipids were examined by measurement of biomarkers before and after a meal. We gathered data before and after 6-month treatment in diabetic patients. Results: After treating 31 patients with teneligliptin for 6 months, the blood level of apoB-48, expressed as total area under the curve (tAUC), was significantly decreased. A multiple regression analysis of factors affecting the decreases in apoB-48 tAUC indicated that apoB-48 is more likely to decrease if it is higher at the start of testing, and that the apoB-48 tAUC value is more likely to fall in women than in men. Conclusions: Teneligliptin may be beneficial for the treatment of postprandial hyperlipidemia in diabetic patients. J Endocrinol Metab. 2020;10(3-4):79-88 doi: https://doi.org/10.14740/jem679

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Teneligliptin对血脂的影响：餐前餐后生物标志物比较的前瞻性研究

背景：在糖尿病的治疗中，预防血脂异常是重要的并发症之一。然而，没有研究检测替尼利汀对2型糖尿病患者餐后载脂蛋白B（apoB）血液参数的长期影响。方法：通过餐前和餐后生物标志物的测定，观察替利利汀对血糖和血脂的影响。我们收集了糖尿病患者治疗6个月前后的数据。结果：31例患者在接受替尼利汀治疗6个月后，apoB-48（以曲线下总面积（tAUC）表示）的血液水平显著降低。对影响apoB-48 tAUC降低的因素进行的多元回归分析表明，如果在测试开始时apoB-48更高，则apoB-48更有可能降低，并且女性的apoB-48 tAUC值比男性更可能下降。结论：Teneliglitin可能对糖尿病患者餐后高脂血症的治疗有益。内分泌代谢杂志。2020年；10（3-4）：79-88 doi:https://doi.org/10.14740/jem679

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来源期刊

Journal of Endocrinology and Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

0.70

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0.00%

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