Association of Endothelin-Converting Enzyme and Endothelin-1 Gene Polymorphisms with Essential Hypertension in Malay Ethnics

IF 1.4 4区生物学 Q4 GENETICS & HEREDITY

Genetics research Pub Date : 2022-05-16 DOI:10.1155/2022/9129960

Elnaz Salim, V. Ramachandran, Neda Ansari, P. Ismail, M. H. Mohamed, N. Mohamad, Liyana Najwa Inche Mat

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引用次数: 2

Abstract

Objectives Endothelin-1 (ET-1), the most potent endogenous vasoconstrictor, generated by enzymatic cleavage catalyzed by an endothelin-converting enzyme (ECE), plays a significant role in the regulation of hypertension. Methods This study investigates the effect of endothelin-1 (Lys198Asn/rs5370) and ECE (rs212526 C/T) gene polymorphisms with essential hypertension (EH) among Malay ethnics. To determine the association of gene polymorphism, 177 hypertensives and controls (196) were genotyped using Taqman method. Results A significant difference was observed in ET-1 rs5370 and ECE rs212526 gene polymorphisms between EH and control subjects (P < 0.001). A significantly high body mass index (BMI), waist-to-hip ratio, fasting plasma glucose, hemoglobin A1c, systolic and diastolic blood pressure, and lipid profiles were observed among the EH patients when compared to controls (P < 0.05). Moreover, T allele (rs5370) carriers in males have a high risk for EH. There was no significant association between gender in ECE C/T polymorphisms (P > 0.05). Conclusion Based on our result, it is evident that the T allele of ET-1 rs5370 polymorphism and C allele of ECE rs212526 have a significant genetic risk factor in EH among Malay subjects, and BMI and age are associated with hypertension.

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内皮素转换酶和内皮素-1基因多态性与马来族原发性高血压的关系

目的内皮素-1（ET-1）是内皮素转化酶（ECE）催化酶切产生的最有效的内源性血管收缩剂，在高血压的调节中发挥重要作用。方法探讨内皮素-1（Lys198Asn/rs5370）和ECE（rs212526C/T）基因多态性与马来族原发性高血压（EH）的关系。为了确定基因多态性的相关性，使用Taqman方法对177名高血压患者和对照组（196）进行了基因分型。结果EH患者ET-1 rs5370和ECE rs212526基因多态性与对照组比较有显著性差异（P＜0.001）。EH患者的体重指数（BMI）、腰臀比、空腹血糖、血红蛋白A1c、收缩压和舒张压以及血脂水平均显著高于对照组（P＜0.05），男性T等位基因（rs5370）携带者是EH的高危人群，ECE C/T多态性与性别无显著相关性（P>0.05）。

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来源期刊

Genetics research 生物-遗传学

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： Genetics Research is a key forum for original research on all aspects of human and animal genetics, reporting key findings on genomes, genes, mutations and molecular interactions, extending out to developmental, evolutionary, and population genetics as well as ethical, legal and social aspects. Our aim is to lead to a better understanding of genetic processes in health and disease. The journal focuses on the use of new technologies, such as next generation sequencing together with bioinformatics analysis, to produce increasingly detailed views of how genes function in tissues and how these genes perform, individually or collectively, in normal development and disease aetiology. The journal publishes original work, review articles, short papers, computational studies, and novel methods and techniques in research covering humans and well-established genetic organisms. Key subject areas include medical genetics, genomics, human evolutionary and population genetics, bioinformatics, genetics of complex traits, molecular and developmental genetics, Evo-Devo, quantitative and statistical genetics, behavioural genetics and environmental genetics. The breadth and quality of research make the journal an invaluable resource for medical geneticists, molecular biologists, bioinformaticians and researchers involved in genetic basis of diseases, evolutionary and developmental studies.