Simultaneous Electrocatalytic Measurement of Dopamine and Acetaminophen by Nanosensor Based on Ag@Polyoxometalate@Reduced Graphene Oxide and Ionic Liquid
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引用次数: 1
Abstract
A novel electrochemical nanosensor was established for the simultaneous measurement of dopamine (DA) and acetaminophen (AC). The nanosensor was achieved by modification of carbon paste electrode (CPE) by Ag nanoparticle, polyoxometalate, reduced graphene oxide (Ag@POM@rGO), and ionic liquid (IL). The electrochemical behaviors of DA and AC were evaluated by Ag@POM@rGO-IL/CPE and various electrochemical methods. Design-Expert software by response surface methodology (RSM) approach was utilized to consider the interaction between the different factors. The best electrochemical response was attained with 0.01 g of IL and 0.04 g of Ag@POM@rGO in the modified electrode, phosphate buffer solution (0.1 M, pH 7.0), and a sweep rate of 0.07 V s−1. In the optimum situation, the calibration curves for DA and AC were achieved in a square wave voltammetry (SWV) manner, and linear dynamic ranges (LDR) were obtained to be 0.05–115.04 µM and 0.1–137.90 µM for DA and AC, respectively. The limit of detection (LOD) was attained to be 17.0 for DA and 37.0 nM for AC. The Ag@POM@rGO-IL/CPE showed good stability, productivity and repeatability, and advanced recovery, and it has a little price and low background current. Also, the usage of this nanosensor was studied by measuring the DA and AC in the human plasma by means of worthy recovery. This technique is easy, rapid, and cheap and can be utilized as a significant device in the quantitative analysis of the medicinal product.
建立了一种新型的电化学纳米传感器，用于同时测量多巴胺(DA)和对乙酰氨基酚(AC)。该纳米传感器采用银纳米粒子、多金属氧酸盐、还原氧化石墨烯(Ag@POM@rGO)和离子液体(IL)对碳糊电极(CPE)进行改性而制成。通过Ag@POM@rGO-IL/CPE和各种电化学方法对DA和AC的电化学行为进行了评价。采用响应面法(RSM)设计专家软件来考虑不同因素之间的相互作用。在磷酸缓冲溶液(0.1 M, pH 7.0)中加入0.01 g IL和0.04 g Ag@POM@rGO，扫描速率为0.07 V s−1时，电化学响应最佳。在最佳条件下，DA和AC的标定曲线采用方波伏安法(SWV)得到，DA和AC的线性动态范围LDR分别为0.05 ~ 115.04µM和0.1 ~ 137.90µM。样品的检出限(LOD)为17.0 nM, AC为37.0 nM。Ag@POM@rGO-IL/CPE具有良好的稳定性、生产效率和重复性，回收率高，价格便宜，背景电流小。并通过对人体血浆中DA和AC的有价值回收，研究了该纳米传感器的应用。该方法简便、快速、廉价，可作为药品定量分析的重要手段。图形抽象
期刊介绍：
Electrocatalysis is cross-disciplinary in nature, and attracts the interest of chemists, physicists, biochemists, surface and materials scientists, and engineers. Electrocatalysis provides the unique international forum solely dedicated to the exchange of novel ideas in electrocatalysis for academic, government, and industrial researchers. Quick publication of new results, concepts, and inventions made involving Electrocatalysis stimulates scientific discoveries and breakthroughs, promotes the scientific and engineering concepts that are critical to the development of novel electrochemical technologies.
Electrocatalysis publishes original submissions in the form of letters, research papers, review articles, book reviews, and educational papers. Letters are preliminary reports that communicate new and important findings. Regular research papers are complete reports of new results, and their analysis and discussion. Review articles critically and constructively examine development in areas of electrocatalysis that are of broad interest and importance. Educational papers discuss important concepts whose understanding is vital to advances in theoretical and experimental aspects of electrochemical reactions.
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