Association between vitamin D and malignant mammary tumors in obese female dogs

Q4 Veterinary
L. C. Nascimento-Hama, R. Vasconcelos, A. D. de Nardi, A. C. de Camargo, Larissa R. Marchini, F. D. L. Rocha, B. Firmo, C. V. Estrada, S. Artoni, N. Nunes, A. R. Panosso, L. Amoroso
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引用次数: 1

Abstract

Overweight and obesity are known risk factors that are involved in the development and aggressiveness of breast tumors in women. In situations of obesity, local and systemic inflammation may worsen the prognosis of oncological patients. Moreover, hypovitaminosis D increases the risk of breast tumors in women. In female dogs, low vitamin D levels have been found in cases of lymphoma, osteosarcoma and mast cell tumor. The present study aimed to make correlations between body fat composition and serum 25(OH)D concentration in female dogs with mammary tumors. Two experimental groups were formed: healthy female dogs (n = 12; control group) and female dogs with mammary tumors (n = 11). An analysis on body composition was performed using dual-energy X-ray absorptiometry (DXA) equipment. In the tumor group, multicentric nodules were most prevalent (63,6%), with diameters of up to 8.2 cm. The most frequent histopathological diagnosis was tubular carcinoma (45.5%), and 9.1% presented metastases in axillary lymph nodes. The mean 25(OH)D concentration in the female dogs with mammary tumors (37.6 ng mL-1) was lower than the level in the control group (65.4 ng mL-1). Multivariate statistical analysis showed that elderly female dogs with malignant mammary tumors and high body fat levels presented lower 25(OH)D concentrations than those of the control group. It was concluded that female dogs with higher body adiposity presented mammary tumors of higher aggressivity, and that the higher the fat percentage was in the female dogs with malignant mammary tumors, the lower their vitamin D concentration was.
维生素D与肥胖雌性犬恶性乳腺肿瘤的关系
超重和肥胖是已知的与女性乳腺肿瘤的发展和侵袭性有关的危险因素。在肥胖的情况下,局部和全身炎症可能会恶化肿瘤患者的预后。此外,维生素D缺乏症会增加女性患乳腺肿瘤的风险。在雌性犬中,在淋巴瘤、骨肉瘤和肥大细胞瘤的病例中发现维生素D水平低。本研究旨在探讨雌性乳腺肿瘤犬体脂组成与血清25(OH)D浓度的相关性。实验分为两组:健康母狗(n = 12);对照组)和乳腺肿瘤母犬(n = 11)。采用双能x射线吸收仪(DXA)设备进行体成分分析。在肿瘤组中,多中心结节最为常见(63.6%),直径可达8.2 cm。最常见的组织病理学诊断为小管癌(45.5%),9.1%为腋窝淋巴结转移。雌性乳腺肿瘤犬体内25(OH)D平均浓度(37.6 ng mL-1)低于对照组(65.4 ng mL-1)。多因素统计分析显示,患有恶性乳腺肿瘤、体脂水平较高的老年母犬25(OH)D浓度低于对照组。由此可见,体脂率高的母狗乳腺肿瘤具有较高的侵袭性,恶性乳腺肿瘤母狗脂肪率越高,其维生素D浓度越低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Brazilian Journal of Veterinary Pathology
Brazilian Journal of Veterinary Pathology Veterinary-Veterinary (miscellaneous)
CiteScore
0.60
自引率
0.00%
发文量
24
期刊介绍: The Brazilian Journal of Veterinary Pathology is the official electronic periodical of the Brazilian Association of Veterinary Pathology. The purpose of the BJVP is to publish original full papers, short communications, case reports, letters, reviews (by invited experts) and abstracts of scientific meetings. The preferable subjects is natural and experimental pathology. All the articles are submitted to scientific reviewers.
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