Shen-Qi-Di-Huang Decoction Prevents Cisplatin-Induced Kidney and Liver Injury by Inhibiting Apoptosis

Abstract

Purpose: This research delves into the procedure in the pathogenesis of Cisplatin (CIS)-caused liver and kidney impairment and check the defensive effect of shen-qi-di-huang decoction (SQDH). Methods: It divides adult male Wistar rats into four groups of eight animals each: Regulation; SQDH; CIS and SQDH+CIS group. They performed multiple analysis to dissect the mechanisms constraining the implements of SQDH. Results: The stems display that pretreatment with SQDH protects the rats from CIS-induced experience and kidney trauma, as disclosed by diminished degrees of serum ALT, AST, BUN and creatinine, improved histopathological damage in thriving and courage. SQDH significantly reverses CIS-induced dysregulation of apoptotic proteins in liver and kidney. In supplement, SQDH induces the activations of PI3K/AKT in kidney and p38/MAPK in liver, individually. Conclusion: We confirm that SQDH protects against CIS-induced nephrotoxicity and hepatotoxicity, which is probably correlated with the activation of p38/MAPK in liver and PI3K/AKT in kidney.