Ormona® SI and Ormona® RC—New Nutraceuticals with Geranylgeraniol, Tocotrienols, Anthocyanins, and Isoflavones—Decrease High-Fat Diet-Induced Dyslipidemia in Wistar Rats

Nutraceuticals Pub Date : 2022-10-26 DOI:10.3390/nutraceuticals2040024

A. P. Rodrigues, Raimundo da Silva Barbosa, Arlindo César Matias Pereira, M. A. Batista, Priscila Faimann Sales, A. M. Ferreira, Nayara Nilcia Dias Colares, Heitor Ribeiro da Silva, Marcelo Oliveira dos Santos Soares, Lorane Izabel da Silva Hage-Melim, J. C. T. Carvalho

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引用次数: 3

Abstract

Dyslipidemia is a metabolic condition linked to increased morbidity. This study aimed to evaluate the effect of two new nutraceuticals derived from annatto (Bixa orellana), açaí (Euterpe oleracea), and soybean germ or red clover isoflavones (Trifolium pratense) against high-fat-induced dyslipidemia in female Wistar rats. The formulations were assessed through GC-MS and HPLC-UV/Vis. Next, female Wistar rats received daily administrations of coconut oil and were treated with Ormona® SI (OSI), Ormona® RC (ORC), soybean germ (SG), simvastatin (simv.), simvastatin + Ormona® SI (simv. + OSI), or only distilled water (control). Biochemical tests were performed using the animals’ blood, and their arteries were screened for atheroma formation. The results show abnormal TC, TG, LDL, and HDL levels caused by the high-fat diet, increased glucose levels, hepatotoxicity, nephrotoxicity, and atherogenesis. The nutraceuticals significantly ameliorated all conditions, with results that are similar to the group treated with simvastatin. Notably, the groups treated with either Ormona® or simvastatin + Ormona® had better liver protection than those treated only with SG or simvastatin; additionally, the nutraceuticals could prevent atherogenesis, unlike SG. The results indicate a high efficacy of the nutraceuticals in preventing dyslipidemia and its complications.

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Ormona®SI和Ormona®rc -含有香叶香叶醇、生育三烯醇、花青素和异黄酮的新型营养保健品-降低Wistar大鼠高脂肪饮食诱导的血脂异常

血脂异常是一种与发病率增加有关的代谢性疾病。本研究旨在评估两种新的源自红木（Bixa orellana）、açaí（Euterpe oleracea）和大豆胚芽或红三叶异黄酮（Trifolium pratense）的营养品对雌性Wistar大鼠高脂诱导的血脂异常的影响。通过GC-MS和HPLC-UV/Vis对制剂进行了评价。接下来，雌性Wistar大鼠每天服用椰子油，并用Ormona®SI（OSI）、Ormona™RC（ORC）、大豆胚芽（SG）、辛伐他汀（simv.）、辛伐他汀+Ormona？SI（simv.+OSI）或仅用蒸馏水（对照）处理。使用动物的血液进行生化测试，并对其动脉进行动脉粥样硬化形成筛查。结果显示，高脂饮食引起的TC、TG、LDL和HDL水平异常、葡萄糖水平升高、肝毒性、肾毒性和动脉粥样硬化形成。这些营养品显著改善了所有情况，其结果与辛伐他汀治疗组相似。值得注意的是，接受奥莫纳®或辛伐他汀+奥莫纳治疗的组比仅接受SG或辛伐他汀治疗的组具有更好的肝脏保护作用；此外，与SG不同，这些营养品可以预防动脉粥样硬化的发生。结果表明，这些营养品在预防血脂异常及其并发症方面具有很高的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nutraceuticals

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