A Modified Method for Increasing Radiochemical Purity of I-125 for Radiopharmaceuticals

IF 0.6 Q4 NUCLEAR SCIENCE & TECHNOLOGY

Atom Indonesia Pub Date : 2023-03-24 DOI:10.55981/aij.2023.1243

M. Maiyesni, M. Mujinah, D. Kurniasih, W. Witarti, H. Hambali, S. Febrianti, I. Kambali

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引用次数: 0

Abstract

Iodine-125 (125I) is one of the radioisotopes widely used in radiopharmaceuticals for diagnosis and therapy of various cancers. Recent reports indicate that there has been shortages in the world supply of this radioiodine isotope. One of the absolute requirements good radiopharmaceuticals must meet is radiochemical purity, which generally has to be above 95 %, with an efficiency of over 90 %. The previous investigation shows that the radiochemical purity is low and does not meet the radiochemical requirement. In this work, we aim at improving the previous method by modifying the Jones reductor-based method. The modified method includes reduction and uniformization of Zn particle sizes, Zn particle compaction, and the performance of reduction process in a closed process flow. The Jones reductor converted impurities into products; in this case, iodate (IO3-) and periodate (IO4-) impurities were converted into iodide (I-), so that 125I product fulfills the radiochemical purity requirements and yielded high efficiency. In this investigation, the 125I previous product was, for the first time, improved with a radiochemical purity of 99.24 % and an efficiency of 97.98 %.

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提高放射性药物I-125放射化学纯度的改进方法

碘-125（125I）是放射性药物中广泛用于诊断和治疗各种癌症的放射性同位素之一。最近的报告表明，这种放射性碘同位素的世界供应短缺。良好的放射性药物必须满足的绝对要求之一是放射化学纯度，通常必须高于95%，效率超过90%。先前的研究表明，放射化学纯度低，不符合放射化学要求。在这项工作中，我们旨在通过修改基于Jones约简器的方法来改进以前的方法。改进的方法包括Zn颗粒尺寸的还原和均匀化、Zn颗粒压实以及在封闭工艺流程中进行还原过程。琼斯还原机将杂质转化为产品；在这种情况下，碘酸盐（IO3-）和高碘酸盐（IO4-）杂质被转化为碘化物（I-），使得125I产物满足放射化学纯度要求并产生高效。在这项研究中，125I以前的产品首次得到改进，放射化学纯度为99.24%，效率为97.98%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Atom Indonesia NUCLEAR SCIENCE & TECHNOLOGY-

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： The focus of Atom Indonesia is research and development in nuclear science and technology. The scope of this journal covers experimental and analytical research in nuclear science and technology. The topics include nuclear physics, reactor physics, radioactive waste, fuel element, radioisotopes, radiopharmacy, radiation, and neutron scattering, as well as their utilization in agriculture, industry, health, environment, energy, material science and technology, and related fields.