Synthesis of highly stable κ/ι-hybrid carrageenan micro- and nanogels via a sonication-assisted microemulsion route

Q2 Materials Science

Polymers from Renewable Resources Pub Date : 2020-08-01 DOI:10.1177/2041247920960973

S. Rodriguez, F. Torres, Junior Arroyo, K. N. Gonzales, O. Troncoso, D. López

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引用次数: 12

Abstract

Novel carrageenan micro- and nanogels were developed via a sonication-assisted microemulsion processing route. The diameter of the dry samples ranged 197.3 −421.35 nm whereas the diameter of the samples suspended in water ranged 467.8–605.9 nm. Hybrid κ/ι-carrageenan, rather than κ- or ι-carrageenan was used for the first time for the preparation of micro- and nanogels. KCl was used as a cross-linking agent and Tween 80 was used as surfactant. The micro- and nanogels suspended in water were found to simultaneously exhibit a lower diameter, and a lower swelling ratio with higher Tween 80 content. The micro- and nanogel suspension yields a zeta potential value of −50.5 mV, superior to values reported elsewhere for pure κ- or ι-carrageenan micro- and nanogels. The high stability was attributed to the high hydrophile-lipophile balance (HLB = 15) value of Tween 80. These results suggest that hybrid κ/ι-carrageenan micro- and nanogels are promising candidates for smart therapeutics applications.

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超声辅助微乳液法合成高稳定性κ/ι-杂化卡拉胶微纳凝胶

采用超声辅助微乳液工艺制备了新型卡拉胶微凝胶和纳米凝胶。干样品的直径范围为197.3−421.35 nm，而悬浮在水中的样品的直径为467.8–605.9 nm。首次使用κ/ι-卡拉胶杂化物，而不是κ-或ι-卡拉胶制备微凝胶和纳米凝胶。KCl用作交联剂，Tween 80用作表面活性剂。发现悬浮在水中的微凝胶和纳米凝胶在吐温80含量较高的情况下同时表现出较低的直径和较低的溶胀率。微凝胶和纳米凝胶悬浮液的ζ电位值为−50.5 mV，优于其他地方报道的纯κ-或ι-卡拉胶微凝胶和纳凝胶的电位值。高稳定性归因于吐温80的高亲水-亲脂平衡（HLB＝15）值。这些结果表明，κ/ι-卡拉胶微凝胶和纳米凝胶是智能治疗应用的有前途的候选者。

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来源期刊

Polymers from Renewable Resources Materials Science-Polymers and Plastics

CiteScore

3.50

自引率

0.00%

发文量

期刊介绍： Polymers from Renewable Resources, launched in 2010, publishes leading peer reviewed research that is focused on the development of renewable polymers and their application in the production of industrial, consumer, and medical products. The progressive decline of fossil resources, together with the ongoing increases in oil prices, has initiated an increase in the search for alternatives based on renewable resources for the production of energy. The prevalence of petroleum and carbon based chemistry for the production of organic chemical goods has generated a variety of initiatives aimed at replacing fossil sources with renewable counterparts. In particular, major efforts are being conducted in polymer science and technology to prepare macromolecular materials based on renewable resources. Also gaining momentum is the utilisation of vegetable biomass either by the separation of its components and their development or after suitable chemical modification. This journal is a valuable addition to academic, research and industrial libraries, research institutions dealing with the use of natural resources and materials science and industrial laboratories concerned with polymer science.