Synthesis, Characterization and Biological Evaluation of Glycogen Synthase Kinase-3β Inhibitors as Antidiabetic Agents

Abstract

Diabetes is a substantially growing unhealthiest in the globe that causes severe morbidity and mortality. Currently a day’s there’s an imperative for the invention, development and improvement of novel antidiabetic drug molecules. A chain of compound (5-imidazol-2-yl-4-phenylpyrimidin-2-yl) [2-(2- pyridyl amino) ethyl] amine were developed and synthesized by using suitable chemical synthetic techniques. These recently synthesized derivatives were characterized with the help of modern analytical techniques. This compound was evaluated for glycogen synthase kinase-3 enzyme inhibitor activities for managing of polygenic disease. GSK-3 inhibitors may advance and emerge as a novel strategy for the management of diabetes.