Factors associated with adherence to antiretroviral therapy among HIV + Patients in Guangxi, China

IF 0.4 Q4 SOCIAL WORK

Journal of HIV-AIDS & Social Services Pub Date : 2019-01-02 DOI:10.1080/15381501.2019.1584138

Zhiwen Xiao, Xiaoming Li, S. Qiao, Yuejiao Zhou, Zhiyong Shen

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Abstract

Abstract This study employed logistic regression to examine the factors that predict medication adherence among a total of 2,146 HIV-infected individuals who were receiving antiretroviral therapy (ART) in Guangxi, China. Of these participants, 1,388 patients (64.7%) did not miss any medication dose. Medication-specific social support (OR = 1.50, 95% CI: 1.05–2.13), no/less experience of influential side effects (OR = 1.38, 95% CI: 1.05–1.81), and direct coping (OR = 1.11, 95% CI: 1.01–1.22) are significant predictors of never missing doses. However, longer duration of receiving ART (OR = 1.60, 95% CI: 1.00–2.57), ever use of synthetic drugs (OR = 2.70, 95% CI: 1.58–4.61), and actively social support seeking (OR = .95, 95% CI: .90–.99) are significant predictors of ever missing adherence. HIV treatment and care in Guangxi should address potential treatment fatigue, offer medication-specific social support, and help patients to prevent, reduce, or manage side effects of treatment. Continuing research is greatly needed on the influence of coping strategies on medication adherence.

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中国广西HIV阳性患者坚持抗逆转录病毒治疗的相关因素

摘要本研究采用logistic回归方法，对中国广西2146名接受抗逆转录病毒疗法（ART）的HIV感染者进行了药物依从性预测因素的检验。在这些参与者中，1388名患者（64.7%）没有错过任何药物剂量。药物特异性社会支持（OR=1.50，95%CI:1.05-2.13）、无/无影响副作用经历（OR=1.38，95%CI:1.05–1.81）和直接应对（OR=1.11，95%CI:1.01–1.22）是从不错过剂量的重要预测因素。然而，接受ART的持续时间较长（OR=1.60，95%CI:1.00-2.57），曾使用过合成药物（OR=2.70，95%CI:1.58-4.61），并积极寻求社会支持（OR = .95，95%可信区间：.90–.99）是持续性依从性缺失的重要预测因素。广西的HIV治疗和护理应解决潜在的治疗疲劳问题，提供针对药物的社会支持，并帮助患者预防、减少或管理治疗的副作用。非常需要继续研究应对策略对药物依从性的影响。

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来源期刊

Journal of HIV-AIDS & Social Services SOCIAL WORK-

CiteScore

1.60

自引率

0.00%

发文量