Association of Insulin Secretion Level on Lipid Fractions and Risk of Arterial Hypertension

Q4 Medicine
Majda Dali-Sahi, Nouria Dennouni-Medjati, Youssouf Kachekouche, Hamza N.M. Boudia, H. Boulenouar
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Abstract

The existing literature reports results on the association of lipid parameters with the level of insulin secretion and the risk of arterial hypertension. This study evaluated the role of the insulin dosage and lipid fractions in the risk of arterial hypertension in type 2 diabetic patients in Western Algeria. This was a cross-sectional observational study involving 101 subjects with type 2 diabetes mellitus. The data collected was about the biodemographic profile of the participants. We performed multiple regressions to test the effect of insulin concentration on the parameters studied. The multiple regression analytical study showed that HOMA-IR, BMI and waist circumference were predictors for the insulinemia response variable (P<0.05). It should be noted that in insulinopenia, insulin secretion is positively and significantly correlated with non-HDL-C (P=0.037), and it is also significantly and positively correlated with LDL-C (P=0.042). Multiple regression also shows that SBP and DBP are significantly and positively related to insulin resistance. Our data suggest a possible direct relationship between fasting insulin and blood pressure. Monitoring of circulating insulin concentrations is critically important in a population of type 2 diabetics.
血脂部分胰岛素分泌水平与动脉高血压风险的关系
现有文献报道了血脂参数与胰岛素分泌水平和动脉性高血压风险之间的关系。本研究评估了胰岛素剂量和脂质组分在阿尔及利亚西部2型糖尿病患者动脉高血压风险中的作用。这是一项横断面观察性研究,涉及101名2型糖尿病患者。收集的数据是关于参与者的生物人口统计资料。我们采用多元回归检验胰岛素浓度对研究参数的影响。多元回归分析研究显示,HOMA-IR、BMI和腰围是胰岛素血症反应变量的预测因子(P<0.05)。值得注意的是,在胰岛素缺乏时,胰岛素分泌与非hdl - c呈显著正相关(P=0.037),与LDL-C呈显著正相关(P=0.042)。多元回归也显示收缩压和舒张压与胰岛素抵抗呈显著正相关。我们的数据表明空腹胰岛素和血压之间可能存在直接关系。监测循环胰岛素浓度对2型糖尿病患者至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Open Hypertension Journal
Open Hypertension Journal Medicine-Cardiology and Cardiovascular Medicine
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