Sub-chronic toxicity of broflanilide on the nervous system of zebrafish (Danio rerio)

IF 1.3 4区环境科学与生态学 Q3 ECOLOGY

Chemistry and Ecology Pub Date : 2022-12-05 DOI:10.1080/02757540.2022.2153836

Kai Wang, Zhiqiu Qi, Manman Duan, Ru Zhang, Lu He

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Abstract

ABSTRACT The new insecticide broflanilide, which possesses high insecticidal activity against agricultural pests, acts on the γ-aminobutyric acid receptor in the insect nervous system. At present, few studies assessed its effect on the nervous system of zebrafish, especially its sub-chronic toxicity on the zebrafish brain. In this study, the sub-chronic toxicity of broflanilide on the zebrafish brain was assessed. After 21 days of exposure at 36.3 μg/L, broflanilide caused oxidative damage to the zebrafish brain, increased the levels of reactive oxygen species and malondialdehyde, and inhibited the activities of superoxide dismutase, catalase, and glutathione peroxidase. Overall, these changes result in brain cell apoptosis, and inhibited growth and development. Moreover, broflanilide affects the release of acetylcholinesterase, γ-aminobutyric acid, 5-hydroxy tryptamine, and dopamine as well as the expression of related genes in the brain, leading to abnormal zebrafish behaviour. These results corroborate the sub-chronic toxicity of broflanilide on zebrafish brain, which helps the further understanding of the potential environmental risk of broflanilide.

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溴flanilide对斑马鱼神经系统的亚慢性毒性

新型杀虫剂溴flanilide作用于昆虫神经系统的γ-氨基丁酸受体，对农业害虫具有较高的杀虫活性。目前很少有研究评估其对斑马鱼神经系统的影响，特别是其对斑马鱼大脑的亚慢性毒性。本研究评估了溴氟胺对斑马鱼大脑的亚慢性毒性。在36.3 μg/L浓度下暴露21 d后，溴flanilide对斑马鱼大脑造成氧化损伤，增加活性氧和丙二醛水平，抑制超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶的活性。总的来说，这些变化导致脑细胞凋亡，抑制生长发育。此外，溴flanilide影响大脑中乙酰胆碱酯酶、γ-氨基丁酸、5-羟基色胺和多巴胺的释放以及相关基因的表达，导致斑马鱼行为异常。这些结果证实了溴氰胺对斑马鱼大脑的亚慢性毒性，有助于进一步了解溴氰胺的潜在环境风险。

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来源期刊

Chemistry and Ecology 环境科学-环境科学

CiteScore

4.20

自引率

16.00%

发文量

审稿时长

3.7 months

期刊介绍： Chemistry and Ecology publishes original articles, short notes and occasional reviews on the relationship between chemistry and ecological processes. This journal reflects how chemical form and state, as well as other basic properties, are critical in their influence on biological systems and that understanding of the routes and dynamics of the transfer of materials through atmospheric, terrestrial and aquatic systems, and the associated effects, calls for an integrated treatment. Chemistry and Ecology will help promote the ecological assessment of a changing chemical environment and in the development of a better understanding of ecological functions.