Breast carcinoma with osteoclastic-like giant cells: a clinicopathological analysis of 2 cases

Q4 Medicine

肿瘤研究与临床 Pub Date : 2020-02-28 DOI:10.3760/CMA.J.ISSN.1006-9801.2020.02.011

Xiaowei Zhu, Fuxing Liu, Guihong Dai, Xiaoqin Jiang, Wenchao Wang, Min Chen, Y. Yang, Hong-jie Yu

引用次数: 0

Abstract

目的探讨伴破骨细胞样巨细胞的乳腺癌（COGC）的临床病理特征。方法收集2016年2月江苏省泰州市人民医院和2008年5月上海市普陀区中心医院COGC患者各1例，观察其组织学形态、免疫表型及临床病理特征，并复习相关文献。结果 2例患者均为女性，年龄分别为48岁及57岁，均因乳房无痛性肿块就诊。光学显微镜下主要表现为浸润性筛状癌及非特殊类型浸润性导管癌，破骨细胞样巨细胞散布在肿瘤组织内，间质内有不同程度的出血和炎症细胞浸润。免疫组织化学示癌细胞雌激素受体（ER）、孕激素受体（PR）弥漫强阳性，破骨细胞样巨细胞CD68阳性。结论 COGC是一种罕见肿瘤，其内的破骨细胞样巨细胞形态特殊，需要与多种类型的多核巨细胞鉴别，其诊断及鉴别诊断需要依据形态学特征及免疫表型。

查看原文本刊更多论文

乳腺癌伴破骨样巨细胞2例临床病理分析

Objective To investigate the clinicopathological characteristics of breast cancer with osteoclast like giant cells (COGC). Method: One COGC patient from Taizhou People's Hospital in Jiangsu Province in February 2016 and one COGC patient from Putuo District Central Hospital in Shanghai in May 2008 were collected, and their histological morphology, immune phenotype, and clinical pathological characteristics were observed. Relevant literature was reviewed. The results showed that both patients were female, aged 48 and 57 years respectively, and both sought medical attention due to painless breast masses. Under optical microscopy, the main manifestations are infiltrating cribriform carcinoma and non-specific infiltrating ductal carcinoma, with osteoclast like giant cells scattered within the tumor tissue, and varying degrees of bleeding and inflammatory cell infiltration in the stroma. Immunohistochemistry showed diffuse strong positivity of estrogen receptor (ER) and progesterone receptor (PR) in cancer cells, and CD68 positivity in osteoclast like giant cells. Conclusion: COGC is a rare tumor with a unique morphology of osteoclast like giant cells, which requires differentiation from multiple types of multinucleated giant cells. Its diagnosis and differential diagnosis need to be based on morphological characteristics and immune phenotype.

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍： "Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association. It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.