M. Tesauro, M. Consonni, T. Filippini, L. Mazzini, F. Pisano, A. Chiò, Aniello Esposito, M. Vinceti
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引用次数: 24
Abstract
Abstract Objective and methods: Based on nationwide death certificates, a cluster of amyotrophic lateral sclerosis (ALS) has been reported in the area of Briga (Novara province, northern Italy), known for its severe environmental contamination. We further investigated this finding, by following up with the collection of recent incidence ALS data in 2002–2012 of Novara province, also to assess the possible long-term effects of environmental pollution in that area. Results: In the whole Novara province we identified 106 ALS cases, of which 35 were from the Briga area. Incidence rates of Novara province were 3.98, 5.14 and 2.97 for the total population, males and females, respectively, compared with the Briga area where they were 4.65, 4.27 and 4.98, respectively. The ratio of observed-to-expected ALS cases in the Briga area, using incidence of the rest of Novara province as a reference, was 1.17 (95% CI 0.81–1.62), with a value of 0.83 (95% CI 0.47–1.37) in males and 1.68 (95% CI 1.03–2.60) in females. Conclusions: Overall, our study did not confirm previous findings of an excess ALS incidence in an area characterised by severe environmental heavy metal pollution, and it suggests the need to interpret with caution clusters identified through mortality data.
目的与方法:根据全国死亡证明,在意大利北部诺瓦拉省布里加地区报告了一起肌萎缩性侧索硬化症(ALS)聚集性病例,该地区以环境污染严重而闻名。我们进一步调查了这一发现,通过收集诺瓦拉省2002-2012年最近ALS发病率的数据,也评估了该地区环境污染可能产生的长期影响。结果:在整个Novara省,我们发现106例ALS病例,其中35例来自Briga地区。诺瓦拉省总人口、男性和女性发病率分别为3.98、5.14和2.97,布里加地区发病率分别为4.65、4.27和4.98。以诺瓦拉省其他地区的发病率为参考,布里加地区的ALS观察病例与预期病例之比为1.17 (95% CI 0.81-1.62),其中男性为0.83 (95% CI 0.47-1.37),女性为1.68 (95% CI 1.03-2.60)。结论:总的来说,我们的研究并没有证实之前的研究结果,即在环境重金属污染严重的地区ALS发病率过高,这表明需要谨慎解释通过死亡率数据确定的聚类。
期刊介绍:
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration is an exciting new initiative. It represents a timely expansion of the journal Amyotrophic Lateral Sclerosis in response to the clinical, imaging pathological and genetic overlap between ALS and frontotemporal dementia. The expanded journal provides outstanding coverage of research in a wide range of issues related to motor neuron diseases, especially ALS (Lou Gehrig’s disease) and cognitive decline associated with frontotemporal degeneration. The journal also covers related disorders of the neuroaxis when relevant to these core conditions.