{"title":"Design for order‐of‐addition experiments with two‐level components","authors":"Hengzhen Huang","doi":"10.1111/sjos.12678","DOIUrl":null,"url":null,"abstract":"The statistical design for order‐of‐addition (OofA) experiments has received much recent interest as its potential in determining the optimal sequence of multiple components, for example, the optimal sequence of drug administration for disease treatment. The traditional OofA experiments focus mainly on the sequence effects of components, i.e., the experimenters fix the factor level of each component and observe how the response is affected by varying the sequences of components. However, the components may also have factorial effects in that changing their factor levels in a given sequence can affect the response. In view of this, we consider the design problem for OofA experiments where each component is experimented at two levels. A systematic method is given to construct OofA designs that jointly considers the sequence design and factorial design for all components. By appropriately choosing the sequence and factorial designs, we show that the combination of the two parts results in a balanced design with an economical run size. Moreover, the constructed designs enjoy a number of optimality properties such as D‐, A‐ and E‐optimalities under some empirical models. The design method proposed can be extended to some other practical situations like the number of process variables is different from the number of components, and OofA experiments with multi‐level components.This article is protected by copyright. All rights reserved.","PeriodicalId":49567,"journal":{"name":"Scandinavian Journal of Statistics","volume":" ","pages":""},"PeriodicalIF":0.8000,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scandinavian Journal of Statistics","FirstCategoryId":"100","ListUrlMain":"https://doi.org/10.1111/sjos.12678","RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"STATISTICS & PROBABILITY","Score":null,"Total":0}
引用次数: 1
Abstract
The statistical design for order‐of‐addition (OofA) experiments has received much recent interest as its potential in determining the optimal sequence of multiple components, for example, the optimal sequence of drug administration for disease treatment. The traditional OofA experiments focus mainly on the sequence effects of components, i.e., the experimenters fix the factor level of each component and observe how the response is affected by varying the sequences of components. However, the components may also have factorial effects in that changing their factor levels in a given sequence can affect the response. In view of this, we consider the design problem for OofA experiments where each component is experimented at two levels. A systematic method is given to construct OofA designs that jointly considers the sequence design and factorial design for all components. By appropriately choosing the sequence and factorial designs, we show that the combination of the two parts results in a balanced design with an economical run size. Moreover, the constructed designs enjoy a number of optimality properties such as D‐, A‐ and E‐optimalities under some empirical models. The design method proposed can be extended to some other practical situations like the number of process variables is different from the number of components, and OofA experiments with multi‐level components.This article is protected by copyright. All rights reserved.
期刊介绍:
The Scandinavian Journal of Statistics is internationally recognised as one of the leading statistical journals in the world. It was founded in 1974 by four Scandinavian statistical societies. Today more than eighty per cent of the manuscripts are submitted from outside Scandinavia.
It is an international journal devoted to reporting significant and innovative original contributions to statistical methodology, both theory and applications.
The journal specializes in statistical modelling showing particular appreciation of the underlying substantive research problems.
The emergence of specialized methods for analysing longitudinal and spatial data is just one example of an area of important methodological development in which the Scandinavian Journal of Statistics has a particular niche.