The relationship of sarcopenia in patients undergoing pancreaticoduodenectomy with outcome

Q4 Nursing

中华临床营养杂志 Pub Date : 2018-02-28 DOI:10.3760/CMA.J.ISSN.1674-635X.2018.01.007

Qinmei Cao, Youming Ding, Meng-Kun Chen, Meng-Kun Chen, Bin Wang, Xiaoyan Chen, Kailiang Zhao, Chen Chen

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Abstract

Objective To explore the prognostic value of sarcopenia in patients undergoing pancreaticoduodenectomy. Method Clinicopathologic data and follow-up information of 116 patients undergoing pancreaticoduodenectomy at Renmin Hospital of Wuhan University between March 2011 and August 2016 were collected for statistical analysis. Results Among the 116 patients, the prevalence of sarcopenia was 42.2% (n=49). When compared to the rest of the patients who did not have sarcopenia, the sarcopenia group had longer recovery time [(17.33±6.54)d vs. (13.46±9.32)d, P=0.013] and increased risk of complications (complications in general, 59.2% vs. 38.8%, χ2=4.714, P=0.030; Clavien-Dindo≥3: 26.5% vs. 10.4%, χ2=5.130, P=0.024). Both the Kaplan-Meier survival analysis (P<0.05) and the Cox proportional hazard model (overall survival: hazard ratio=2.285, 95% CI=1.521-3.431; recurrence-free survival, hazard ratio=2.167, 95% CI=1.445-3.248) indicated sarcopenia as the risk factor for poorer overall survival and recurrence-free survival. Conclusions Sarcopenia was an independent predictor of poor prognosis for patients undergoing pancreaticoduodenectomy. Patients with sarcopenia had higher risk of developing complications after surgery and lower overall survival rate and recurrence-free survival rate. Key words: Sarcopenia; Pancreaticoduodenectomy; Complications; Overall survival; Recurrence-free survival

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胰十二指肠切除术患者少肌症与预后的关系

目的探讨少肌症在胰十二指肠切除术中的预后价值。方法收集2011年3月至2016年8月武汉大学人民医院116例胰十二指肠切除术患者的临床病理资料和随访资料进行统计分析。结果116例患者中，少肌症发生率为42.2%（n=49）。当与没有少肌症的其余患者相比时，少肌症组恢复时间较长[（17.33±6.54）d vs.（13.46±9.32）d，P=0.013]，并发症风险增加（一般并发症59.2%vs.38.8%，χ2=4.714，P=0.030；Clavien-Dindo≥3:26.5%vs.10.4%，χ2=5.130，P=0.024）。Kaplan-Meier生存分析（P<0.05）和Cox比例风险模型（总生存率：危险比=2.285，95%CI=1.521～3.431；无复发生存率，危险比=2.167，95%CI=1.445～3.248）表明少肌症是总生存率和无复发生存期较差的危险因素。结论对于接受胰十二指肠切除术的患者而言，肌萎缩是预后不良的独立预测因素。少肌症患者术后发生并发症的风险较高，总生存率和无复发生存率较低。关键词：Sarcopenia；胰十二指肠切除术；并发症；总体生存率；无复发生存率

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来源期刊

中华临床营养杂志 Nursing-Nutrition and Dietetics

CiteScore

0.20

自引率

0.00%

发文量

2282

期刊介绍： The Chinese Journal of Clinical Nutrition was founded in 1993. It is the first professional academic journal (bimonthly) in my country co-sponsored by the Chinese Medical Association and the Chinese Academy of Medical Sciences to disseminate information on clinical nutrition support, nutrient metabolism, the impact of nutrition support on outcomes and "cost-effectiveness", as well as translational medicine and nutrition research. It is also a professional journal of the Chinese Medical Association's Parenteral and Enteral Nutrition Branch. The purpose of the Chinese Journal of Clinical Nutrition is to promote the rapid dissemination of knowledge on nutrient metabolism and the rational application of parenteral and enteral nutrition, focusing on the combination of multidisciplinary and multi-regional field investigations and clinical research. It mainly reports on nutritional risk screening related to the indications of parenteral and enteral nutrition support, "cost-effectiveness" research on nutritional drugs, consensus on clinical nutrition, guidelines, expert reviews, randomized controlled studies, cohort studies, glycoprotein and other nutrient metabolism research, systematic evaluation of clinical research, evidence-based case reports, special reviews, case reports and clinical experience exchanges, etc., and has a special column on new technologies related to the field of clinical nutrition and their clinical applications.