Low survival of advanced laryngeal cancers: Time to change the treatment regime?

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
S. Vijay, S. Thavarool, S. Manu, N. George, R. Nair
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引用次数: 1

Abstract

Background: This study aimed to detect the survival outcome of patients who underwent primary laryngectomy in comparison to the salvage total laryngectomy at our institution. Methodology: A retrospective analysis of patients who underwent laryngectomy in our institution from 2009 to 2016 either as primary surgery or as salvage surgery was done. Results: Fifty-four patients were assessed in the current study. Primary laryngectomy was done in 33 (60.4%) patients and savage laryngectomy in 21 (39.6%) patients. The common complication following laryngectomy was wound infection (68.5%) followed by pharyngocutaneous fistula (29.6%). The five year disease free survival in primary and salvage laryngectomy patients were 46% and 32 % respectively. DFS showed a decreasing trend with increase in T-stage and also node positivity. The overall survival (5 years) was found to be 52% for primary laryngectomy cases and 37% for salvage cases. Conclusion: Salvage laryngectomy was found to have higher incidence of postoperative complications. The overall survival and DFS was found to be lesser for salvage cases than primary laryngectomy. T- and N-stage have an important role in determining survival. The survival of advanced laryngeal cancers is dismal with surgery and radiotherapy.
晚期喉癌的低生存率:是时候改变治疗方案了?
背景:本研究旨在检测在我们机构接受原发性喉切除术和保留性全喉切除术的患者的生存结果。方法:对2009年至2016年在我们机构接受喉切除术的患者进行回顾性分析,无论是原发手术还是挽救手术。结果:本研究对54名患者进行了评估。原发性喉切除术33例(60.4%),野蛮喉切除术21例(39.6%)。喉切除术后最常见的并发症是伤口感染(68.5%),其次是咽皮瘘(29.6%)。原发性和抢救性喉切除术患者的5年无病生存率分别为46%和32%。DFS随着T分期和淋巴结阳性率的增加呈下降趋势。原发性喉切除术的总生存率(5年)为52%,抢救性喉切除术为37%。结论:抢救性喉切除术术后并发症发生率较高。与原发性喉切除术相比,抢救性病例的总生存率和DFS较低。T期和N期在决定生存方面起着重要作用。晚期喉癌的生存率因手术和放疗而惨淡。
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来源期刊
Journal of Head & Neck Physicians and Surgeons
Journal of Head & Neck Physicians and Surgeons MEDICINE, GENERAL & INTERNAL-
CiteScore
0.30
自引率
0.00%
发文量
0
审稿时长
15 weeks
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