Efficacy of hepatoprotectors in prophylaxis of hepatosis of laying hens

IF 0.5 Q4 BIOLOGY

Regulatory Mechanisms in Biosystems Pub Date : 2022-08-04 DOI:10.15421/022237

L. Slivinska, V. Yaremchuk, A. Shcherbatyy, B. Gutyj, H. Zinko

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Abstract

Hepatoses of laying hens are quite common in poultry farms as a result of improper practices of poultry maintenance consisting in excessive number of protein feeds for provision of high productivity. The objective of the study was preventive efficacy of Gep-A-Stress hepatoprotectors (carnitine hydrochloride, D L methionine, sorbitol, choline chloride, magnesium sulfate heptahydrate) and Hepasan VS (L-carnitine hydrochloride, sorbitol, choline chloride, magnesium sulfate hepahydrate, betaine hydrochloride, L-arginin) against hepatosis of laying hens. To determine the efficacy of Hep-A-Stres and Hepasan-VS hepatoprotectors during production tests (n = 4,500), we monitored the parameters of survival rate (the final number of individuals as percentage of the initial number) and egg productivity of laying hens. We determined that after 30 days of using the hepatoprotectors, the content of overall protein in blood serum of laying hens of the first and the second experimental groups decreased by 21.4% and 18.9% compared with the parameters prior to providing the hepatoprotectors and by 26.3% and 23.3% compared with the control group after receiving the drug. The urea contents in blood serum increased by 19.0% and 10.5%. Compared with the control, the activity of alanine aminotransferase decreased by 43.7% and 24.1% in the first experimental group and by 23.4% and 14.9% in the second. The activity of aspartate aminotransferase in blood serum of the experimental groups decreased by 10.7%. The cholesterol concentration decreased by 50% and 58.3%. The content of triaglycerols decreased by 24.1% and 8.9% respectively. The concentrations of high-density lipoproteins after 30 days of the experiment decreased by 33.3% and 77.8% respectively, the content of low-density lipoproteins decreased by 61.3% and 40.4% and 42.3%. Population maintenance equaled respectively 97.1%, 98.3% and 98.1%. At the end of the experiment, the egg productivity of laying hens of the first and second groups increased by 4% and 3.6% compared with the control. Therefore, intake of the hepaprotectors by laying hens stimulated their metabolism, positively influenced the blood parameters, survival and egg productivity. The conducted studies confirm the benefits of using hepatoprotectors for the prohylaxis of hepatosis of hens.

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肝保护剂对蛋鸡肝病的预防作用

在家禽养殖场，蛋鸡的肝病是相当常见的，原因是饲养家禽的不当做法，包括过量的蛋白质饲料，以提供高生产力。研究gep -a应激型护肝剂(盐酸肉碱、dl蛋氨酸、山梨醇、氯化胆碱、七水合硫酸镁)和Hepasan VS(盐酸左旋肉碱、山梨醇、氯化胆碱、硫酸氢镁、盐酸甜菜碱、L-精氨酸)对蛋鸡肝病的预防作用。在生产试验(n = 4,500)中，为了确定hep - a - stress和Hepasan-VS肝保护剂的功效，我们监测了蛋鸡的存活率(最终个体数占初始数量的百分比)和产蛋率参数。我们测定，在使用肝保护剂30 d后，试验组和试验组蛋鸡血清总蛋白含量分别比给予肝保护剂前和给药后分别下降21.4%和18.9%，比对照组分别下降26.3%和23.3%。血清尿素含量分别提高19.0%和10.5%。与对照组相比，第一个试验组丙氨酸转氨酶活性分别下降43.7%和24.1%，第二个试验组分别下降23.4%和14.9%。试验组血清天冬氨酸转氨酶活性降低10.7%。胆固醇浓度分别下降50%和58.3%。甘油三酯含量分别下降24.1%和8.9%。实验30 d后，高密度脂蛋白浓度分别下降33.3%和77.8%，低密度脂蛋白含量分别下降61.3%、40.4%和42.3%。人口维持率分别为97.1%、98.3%和98.1%。试验结束时，1组和2组蛋鸡产蛋率分别比对照组提高了4%和3.6%。由此可见，蛋鸡摄入肝保护剂促进了蛋鸡的新陈代谢，对血液参数、存活率和产蛋率产生了积极影响。所进行的研究证实了使用肝保护剂预防母鸡肝病的益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regulatory Mechanisms in Biosystems BIOLOGY-

CiteScore

0.90

自引率

0.00%

发文量

审稿时长

10 weeks