Evaluation of SOX2 and podoplanin expression in oral epithelial dysplasia and its correlation with malignant transformation

Q1 Medicine

Journal of Investigative and Clinical Dentistry Pub Date : 2019-08-28 DOI:10.1111/jicd.12450

Vani Verma, Chetana Chandrashekar

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引用次数: 5

Abstract

Aim

Oral carcinogenesis cascade is a complex process, characterized by variable numbers of genetic and epigenetic alterations of various genes with manifold roles that could serve as biological hallmarks. This study was undertaken to assess the protein expression of SOX2 and podoplanin in oral epithelial dysplasia and correlate the expression with clinicopathological parameters and risk of malignant transformation.

Methods

SOX2 and podoplanin expression were analyzed in 60 cases of oral epithelial dysplasia. The association between SOX2 and podoplanin expression with various clinicopathological parameters and transformation to oral cancer was analyzed.

Results

A higher Histoscore was seen in 55% of moderate and 30% of severe dysplasia. 25% of the cases showed a negative podoplanin expression and 30% of patients had higher podoplanin expression (score 2 and 3). Though there was significant association of both SOX2 and podoplanin expression with the degree of dysplasia, the association of their expression with transformation to oral squamous cell carcinoma did not reach statistical significance.

Conclusion

Alteration in SOX2 and podoplanin is likely an important event in head and neck carcinogenesis; however, their expression may be valuable only in a few cases of oral epithelial dysplasia to assess the risk of malignant transformation.

查看原文本刊更多论文

口腔上皮异常增生组织中SOX2和podoplanin的表达及其与恶性转化的关系。

恶性肿瘤级联发生是一个复杂的过程，其特点是各种基因的遗传和表观遗传改变的数量不同，这些基因具有多种作用，可以作为生物学标志。本研究旨在评估SOX2和podoplanin蛋白在口腔上皮异常增生中的表达，并将其与临床病理参数和恶性转化风险的关系联系起来。方法对60例口腔上皮发育不良患者进行ssox2和podoplanin的表达分析。分析SOX2和podoplanin表达与各种临床病理参数及向口腔癌转化的关系。结果55%的中度发育不良患者和30%的重度发育不良患者的组织学评分较高。25%的病例podoplanin表达阴性，30%的患者podoplanin表达较高(评分2分和3分)。SOX2和podoplanin表达与发育不良程度均有显著相关性，但与转化为口腔鳞状细胞癌的相关性无统计学意义。结论SOX2和podoplanin的改变可能是头颈部癌变的重要事件;然而，它们的表达可能仅在少数口腔上皮发育不良的病例中有价值，以评估恶性转化的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Investigative and Clinical Dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： Journal of Investigative and Clinical Dentistry (JICD) aims to publish quality, peer reviewed original research and topical reviews on all aspects of investigative and clinical dentistry and craniofacial research, including molecular studies related to oral health and disease. Although international in outlook, the Editor especially encourages papers from the Asia Pacific. The journal also aims to provide clinicians, scientists and students of dentistry with a knowledge transfer platform for rapid publication of reports through an international journal, which will be available free online until 2012. Its scope, therefore, is broad, inclusive and international, but with a particular focus on Asia Pacific. The Editor welcomes manuscripts in the following key thematic areas in oral and maxillofacial sciences: Community Dentistry and Oral Epidemiology, Conservative Dentistry, Dental Biomaterials, Dental Pedagogy, Endodontics and Traumatology, Implant Dentistry, Oral Biosciences, Oral and Maxillofacial Surgery, Oral Medicine, Oral Pathology and Oral Microbiology, Orthodontics, Oral Radiology, Oral Rehabilitation, Paedodontics, Periodontology and Periodontal Medicine.