Hippocampal volume in cases of relapsing remitting multiple sclerosis and its correlation with cognitive impairment

Q4 Medicine

Romanian Journal of Neurology/ Revista Romana de Neurologie Pub Date : 2023-06-30 DOI:10.37897/rjn.2023.2.4

K. Eltoukhy, Ahmed Esmael, A. Abdelkhalek, Asem Nagy

{"title":"Hippocampal volume in cases of relapsing remitting multiple sclerosis and its correlation with cognitive impairment","authors":"K. Eltoukhy, Ahmed Esmael, A. Abdelkhalek, Asem Nagy","doi":"10.37897/rjn.2023.2.4","DOIUrl":null,"url":null,"abstract":"Background. Multiple sclerosis (MS) is a chronic inflammatory immune-mediated disease, distinguished by demyelination and oligodendropathy in the central nervous system. Cognitive impairment (CI) can impact patients at any stage of MS, including those with clinically isolated syndrome (CIS). Patients and methods. This is a prospective cross-sectional study which enrolled 60 patients with RRMS. They were subjected to cognitive scale assessment, routine brain MRI study and volumetric assessment of hippocampus. Results. This study found a significant positive correlation between duration of disease and Subjective memory complaints questionnaire (r=0.525, p=0.001). A significant negative correlation existed between disease duration and MMSE score (r=-0.404, p=0.001) and between disease duration and MoCA score (r=-0.310, p=0.016). No significant difference between both groups regarding the relative hippocampal volume. Mean relative right hippocampal volume is 0.0026 for cases versus 0.0027 among control group and mean relative left hippocampal volume is 0.0025 for cases versus 0.0026 among control group. Conclusion. Multiple sclerosis disease duration had an impact on cognitive state. However, hippocampal volume assessment did not predict the cognitive affection in patient with RRMS.","PeriodicalId":37662,"journal":{"name":"Romanian Journal of Neurology/ Revista Romana de Neurologie","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Romanian Journal of Neurology/ Revista Romana de Neurologie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37897/rjn.2023.2.4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Background. Multiple sclerosis (MS) is a chronic inflammatory immune-mediated disease, distinguished by demyelination and oligodendropathy in the central nervous system. Cognitive impairment (CI) can impact patients at any stage of MS, including those with clinically isolated syndrome (CIS). Patients and methods. This is a prospective cross-sectional study which enrolled 60 patients with RRMS. They were subjected to cognitive scale assessment, routine brain MRI study and volumetric assessment of hippocampus. Results. This study found a significant positive correlation between duration of disease and Subjective memory complaints questionnaire (r=0.525, p=0.001). A significant negative correlation existed between disease duration and MMSE score (r=-0.404, p=0.001) and between disease duration and MoCA score (r=-0.310, p=0.016). No significant difference between both groups regarding the relative hippocampal volume. Mean relative right hippocampal volume is 0.0026 for cases versus 0.0027 among control group and mean relative left hippocampal volume is 0.0025 for cases versus 0.0026 among control group. Conclusion. Multiple sclerosis disease duration had an impact on cognitive state. However, hippocampal volume assessment did not predict the cognitive affection in patient with RRMS.

查看原文本刊更多论文

复发-缓解型多发性硬化症患者的海马体积及其与认知障碍的相关性

背景。多发性硬化症(MS)是一种慢性炎症性免疫介导的疾病，以中枢神经系统脱髓鞘和少突病变为特征。认知障碍(CI)可影响MS任何阶段的患者，包括临床孤立综合征(CIS)患者。患者和方法。这是一项前瞻性横断面研究，纳入了60例RRMS患者。进行认知量表评估、常规脑MRI研究和海马体积评估。结果。本研究发现疾病持续时间与主观记忆抱怨问卷呈显著正相关(r=0.525, p=0.001)。病程与MMSE评分呈显著负相关(r=-0.404, p=0.001)，病程与MoCA评分呈显著负相关(r=-0.310, p=0.016)。两组海马相对体积差异无统计学意义。右侧海马平均相对体积为0.0026，对照组为0.0027;左侧海马平均相对体积为0.0025，对照组为0.0026。结论。多发性硬化症病程对认知状态有影响。然而，海马体积评估并不能预测RRMS患者的认知影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Romanian Journal of Neurology/ Revista Romana de Neurologie Medicine-Neurology (clinical)

CiteScore

0.40

自引率

0.00%

发文量

审稿时长

4 weeks

期刊介绍： ROMANIAN JOURNAL OF NEUROLOGY (Revista Română de Neurologie), the official journal of the Romanian Society of Neurology, was founded in 2001, being a prestigious scientific journal that provides a high quality in terms of scientific content, but also the editorial and graphic aspect, both through an impartial process of selection, evaluation and correction of articles (peer review procedure), as well as providing editorial, graphic and printing conditions at the highest level. In order to increase the scientific standards of the journal, special attention was paid to the improvement of the quality of the published materials. Guidance articles, clinical trials and case studies are structured in several sections: reviews, original articles, case reports, images in neurology. All articles are published entirely in English. A team of reputable medical professionals in the field of neurology is involved in a rigorous peer review process that complies with international ethics and quality rules in the academic world.