Comparison of QTC Interval Before and After Hydroxychloroquine Therapy in COVID-19 Patients at Kendari City Hospital

MedULA Pub Date : 2023-01-31 DOI:10.46496/medula.v10i3.17

Yusuf Musafir Kolewora, Ditha Arisqa, Nasir

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Abstract

Background. Corona Virus Disease 19 (COVID-19) is caused by SARS-COV 2 which is of global public health concern. Hydroxychloroquine is a drug that is thought to be useful in treating COVID-19, but the mechanism of action of this drug is to block potassium channels and potentially extend the QTc interval. The purpose of this study was to determine the difference in QTc intervals before and after hydroxychloroquine therapy in COVID-19 patients at Kendari City Hospital. Methods. This research is an observational analytic study, with a cross-sectional design, which was conducted at the Regional General Hospital of Kendari City. The number of samples in this study were 106 patients. Qtc interval values before and after hydroxychloroquine therapy were collected using medical record data according to the inclusion criteria. Data was processed using paired t test analysis. Results. Bivariate analysis showed that there was a difference in the average Qtc interval before and after hydroxychloroquine therapy (409.02 vs 426.10, p<0.05). Conclusion. There are differences in QTc intervals before and after hydroxychloroquine therapy in COVID-19 patients at Kendari City Hospital.

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肯达里市医院新冠肺炎患者羟氯喹治疗前后QTC间隔的比较

背景冠状病毒病19（新冠肺炎）是由严重急性呼吸系统综合征2型引起的，这是全球公共卫生关注的问题。羟氯喹是一种被认为可用于治疗新冠肺炎的药物，但该药物的作用机制是阻断钾通道并可能延长QTc间期。本研究的目的是确定Kendari市医院新冠肺炎患者在羟氯喹治疗前后QTc间期的差异。方法。这项研究是一项观察性分析研究，采用横断面设计，在肯达里市地区综合医院进行。本研究中的样本数量为106名患者。Qtc区间值根据纳入标准，使用病历数据收集羟氯喹治疗前后的数据。数据采用配对t检验分析进行处理。后果双变量分析显示，羟氯喹治疗前后的平均Qtc间期有差异（409.02 vs 426.10，p<0.05）。肯达里市医院新冠肺炎患者在羟氯喹治疗前后QTc间期存在差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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MedULA MEDICINE, GENERAL & INTERNAL-

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