Evaluation of Biological Activity of 5-Fluoro-Isatin Thiosemicarbazone Derivatives

IF 1.4 Q4 NANOSCIENCE & NANOTECHNOLOGY

Journal of Nanostructures Pub Date : 2020-07-01 DOI:10.22052/JNS.2020.03.007

M. Ramadan, M. Baloğlu, Y. C. Altunoglu, F. Kandemirli, Hakan Burhan, A. Aygün, H. Sayiner, F. Ozyigit, F. Sen

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引用次数: 0

Abstract

Isatin based materials can exhibit a wide range of biological activities including antimicrobial, antiviral, antifungal, anthelmintic, antitumor, anti-HIV, anti-inflammatory, antidepressant, antioxidant, anticonvulsant, antitubercular, analgesic, and central nervous system depressant activities. In this study, four compounds containing 5-Fluoro-isatin thiosemicarbazone with methoxyphenyl or methoxyphenyl in different positions and zinc complexes were evaluated based on their biological activities. Compound 2 was the strongest compound affecting gram-negative bacteria compared to the other compounds. Also, this compound indicated better antimicrobial activity than positive control antibiotics. Besides, compound 3 was the only compound that inhibited the growth of Salmonella spp. such as Salmonella enteritidis ATCC 13076 and Salmonella typhimurium NRRLE 4463. 5-Fluoro-Isatin thiosemicarbazone and its derivatives also showed DNA protection property from moderate to good protections. Among them, compound 4 displayed the highest DNA binding affinity. These compounds possessed a capacity for utilization as drugs or drug additives based on their effects on bacteria strains and DNA binding affinity.

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5-氟-氨基硫脲衍生物的生物活性评价

Isatin基材料具有广泛的生物活性，包括抗菌、抗病毒、抗真菌、驱虫药、抗肿瘤、抗hiv、抗炎、抗抑郁、抗氧化、抗惊厥、抗结核、镇痛和中枢神经系统抑制活性。本研究对4个含5-氟异硫丁硫代氨基脲与甲氧基苯基或甲氧基苯基不同位置的配合物及锌配合物的生物活性进行了评价。与其他化合物相比，化合物2对革兰氏阴性菌的影响最强。与阳性对照抗生素相比，该化合物具有更好的抗菌活性。此外，化合物3是唯一抑制肠炎沙门氏菌ATCC 13076和鼠伤寒沙门氏菌NRRLE 4463等沙门氏菌生长的化合物。5-氟isatin硫代氨基脲及其衍生物对DNA的保护作用也从中等到良好。其中化合物4的DNA结合亲和力最高。基于对细菌菌株的作用和DNA结合亲和力，这些化合物具有作为药物或药物添加剂的利用能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nanostructures NANOSCIENCE & NANOTECHNOLOGY-

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

7 weeks

期刊介绍： Journal of Nanostructures is a medium for global academics to exchange and disseminate their knowledge as well as the latest discoveries and advances in the science and engineering of nanostructured materials. Topics covered in the journal include, but are not limited to the following: Nanosystems for solar cell, energy, catalytic and environmental applications Quantum dots, nanocrystalline materials, nanoparticles, nanocomposites Characterization of nanostructures and size dependent properties Fullerenes, carbon nanotubes and graphene Self-assembly and molecular organization Super hydrophobic surface and material Synthesis of nanostructured materials Nanobiotechnology and nanomedicine Functionalization of nanostructures Nanomagnetics Nanosensors.