Antidiabetic Activity of Date Seed Methanolic Extracts in Alloxan-Induced Diabetic Rats

IF 3.8 3区农林科学 Q1 VETERINARY SCIENCES

Pakistan Veterinary Journal Pub Date : 2019-10-01 DOI:10.29261/pakvetj/2019.099

J. Sharifi‐Rad, S. A. Ayatollahi, Navid Baghalpour

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引用次数: 12

Abstract

Received: Revised: Accepted: Published online: January 30, 2019 June 23, 2019 August 22, 2019 September 11, 2019 Phoenix dactylifera. L. )date palm ( is one of the main fruits in North of Africa and Middle East. The date seeds are considered as wastes despite of their medicinal properties. Different seed preparations are used as expectorant, anti-diarrheic, hypoglycemic, tonic, and aphrodisiac agents. We established the anti-diabetic and antilipidemic activities of methanolic extracts of date seed in alloxan-induced diabetic rats. Animals were divided in to 6 groups (each group contained six animals), comprising of control group and diabetic rats. Animals were treated with different amounts of extract. To assess the hypolipidemic, and anti-hyperglycemic activity, cholesterol serum levels, low density lipoprotein (LDL), high density lipoprotein (HDL), creatinine, urea and alkaline phosphatase were measured in serum of the treated animals. The anti-diabetic potential was investigated through the levels of glucose and body weight. Moreover, to assess the extract’s safety, acute toxicity test was performed. In comparison with control group, significant reductions were observed in LDL, cholesterol, as well as blood glucose levels in diabetic rats that received date seed extract. Extract supplemented diabetic rats also showed a better tolerance to glucose, as well as reduced amounts of creatinine, urea, and alkaline phosphatase in their serum samples. In addition, no toxicity (acute toxicity), was detected even after high dosage of extract administration. Our results confirmed the anti-lipidemic and anti-diabetic potentials of date seed methanolic extract in diabetic rats. ©2019 PVJ. All rights reserved

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椰枣籽甲醇提取物对四氧嘧啶糖尿病大鼠的抗糖尿病作用

接收：修订：接受：在线发布：2019年1月30日2019年6月23日2019年8月22日2019年9月11日凤凰指。L.）椰枣（是非洲北部和中东地区的主要水果之一。椰枣种子尽管具有药用特性，但仍被认为是废物。不同的种子制剂被用作祛痰、抗腹泻、降血糖、滋补和壮阳剂。我们建立了椰枣种子甲醇提取物对四氧嘧啶诱导的糖尿病大鼠的抗糖尿病和抗血脂活性再分为6组（每组6只动物），包括对照组和糖尿病大鼠。用不同量的提取物处理动物。为了评估降脂和抗高血糖活性，测量了治疗动物血清中的胆固醇血清水平、低密度脂蛋白（LDL）、高密度脂蛋白、肌酐、尿素和碱性磷酸酶。通过血糖和体重水平来研究抗糖尿病的潜力。此外，为了评估提取物的安全性，进行了急性毒性试验。与对照组相比，在接受椰枣籽提取物的糖尿病大鼠中，观察到LDL、胆固醇和血糖水平显著降低。补充提取物的糖尿病大鼠对葡萄糖也表现出更好的耐受性，血清样本中的肌酐、尿素和碱性磷酸酶含量也有所降低。此外，即使在高剂量的提取物给药后也未检测到毒性（急性毒性）。我们的研究结果证实了椰枣籽甲醇提取物在糖尿病大鼠中的抗脂和抗糖尿病潜力。©2019 PVJ。保留所有权利

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来源期刊

Pakistan Veterinary Journal 兽医-兽医学

CiteScore

4.20

自引率

13.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Pakistan Veterinary Journal (Pak Vet J), a quarterly publication, is being published regularly since 1981 by the Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan. It publishes original research manuscripts and review articles on health and diseases of animals including its various aspects like pathology, microbiology, pharmacology, parasitology and its treatment. The “Pak Vet J” (www.pvj.com.pk) is included in Science Citation Index Expended and has got 1.217 impact factor in JCR 2017. Among Veterinary Science Journals of the world (136), “Pak Vet J” has been i) ranked at 75th position and ii) placed Q2 in Quartile in Category. The journal is read, abstracted and indexed internationally.