Pattern of Blood Products Transfusions and Reactions among Multi-Transfused Haemophiliacs in Nigeria : Implications on Haemophilia Care in Low Resource Tropical Settings

Sudan medical journal Pub Date : 2018-04-01 DOI:10.12816/0046389

Sagir G. Ahmed, M. Kagu, U. Ibrahim

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引用次数: 3

Abstract

Background: FVIII-concentrate is cornerstone for managing haemophilia-A. Scarcity of FVIII-concentrate compels caregivers in poor countries to adopt less effective therapeutic transfusion strategies with various FVIII-containing blood products including fresh whole blood (FWB), unfrozen fresh plasma (uFP), thawed fresh frozen plasma (tFFP), cryoprecipitate (CP) and stored red cell concentrates (sRCC) for managing haemophilia. This strategy predisposes to sensitizations and immune ______________________________ Corresponding author Sagir G Ahmed Tel: +234 8034418015 Email: drsagirahmed@yahoo.com mediated acute transfusion reactions (IMATRs). Hence in this paper we analyzed the pattern of blood products transfusions and frequencies of IMATRs among multitransfused haemophiliacs in Nigeria. Methods: We determined demographic and clinical data, frequencies of transfusion of each blood product, the prevalence of IMATRs, and the relative frequencies of each type of IMATRs among multi-transfused haemophiliacs. Comparisons between patients with and without IMATRs were done using ttest for mean values and Fisher‘s exact test for frequencies: p values of < 0.05 were taken as significant. Results: Total of 86 haemophiliacs received multiple transfusions of five types of blood products (FWB, uFP, tFFP, sRCC or CP) during study period. The frequencies of

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尼日利亚多次输血的血友病患者的血液制品输血模式和反应：对低资源热带地区血友病护理的影响

背景：FVIII浓缩物是管理血友病-A的基石。FVIII浓缩物的稀缺性迫使贫穷国家的护理人员采用不太有效的治疗性输血策略，使用各种含FVIII的血液制品，包括新鲜全血（FWB）、未冷冻新鲜血浆（uFP）、解冻新鲜冷冻血浆（tFP）、冷冻沉淀物（CP）和储存红细胞浓缩物（sRCC）来治疗血友病。该策略易致敏和免疫______________________________通讯作者Sagir G Ahmed电话：+234 8034418015电子邮件：drsagirahmed@yahoo.com介导的急性输血反应（IMATR）。因此，在本文中，我们分析了尼日利亚多次输血的血友病患者的血液制品输血模式和IMATR频率。方法：我们确定了人口统计学和临床数据、每种血液制品的输血频率、IMATR的流行率以及每种类型IMATR在多次输血的血友病患者中的相对频率。使用平均值的ttest和频率的Fisher精确检验对患有和不患有IMATR的患者进行比较：p值<0.05被认为是显著的。结果：在研究期间，共有86名血友病患者接受了五种类型血液制品（FWB、uFP、tFPP、sRCC或CP）的多次输血。的频率

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Sudan medical journal

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