Clinical and Microbiology Profile of Typhoidal and Nontyphoidal Salmonella Blood Stream Infection: An Observational Study from a University Hospital

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL
Tasneem Siddiqui, R. Sinha, S. Patel, C. Sahu
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Abstract

Abstract Background  Species distribution and antibiotic resistance pattern of Salmonella varies with time and place. Rapid and correct use of antibiotics requires understanding of the distribution and drug resistance patterns. Therefore, we aimed to study the clinical profile of patients along with speciation and antibiogram of Salmonella isolates from blood. Material and Methods  It is an observational study, conducted from December 2019 to December 2021 at our university hospital. Blood cultures were processed by automated blood culture system. Salmonella isolates were identified by their morphological properties, biochemical reaction, and serological tests. Antibiotic susceptibility pattern was assessed by Kirby–Bauer's disc diffusion method and Phoenix automated system. Results  The male-to-female ratio of the patients in the study was 2.5:1 and the mean age of the patients was 11.7 years (1–27 years). Salmonella spp. was isolated from 21 patients out of 1,350 positive blood cultures. Nine isolates were identified as S. Typhi seven as S. Choleraesuis three as S. Paratyphi A and two as S. Paratyphi B. Immunocompromised conditions were significantly associated in nontyphoidal Salmonella bacteremia ( p  = 0.0253). Isolates showed maximum resistance toward nalidixic acid (100%) followed by fluoroquinolones (52.4%). Multidrug resistance, extreme drug resistance, and azithromycin resistance was seen in 14.3, 4.8, and 4.8% isolates, respectively. Posttreatment recovery was observed in 20 patients. Conclusion  Emergence of S. Choleraesuis among Salmonella spp. in blood stream infection, next only to S. Typhi was noted. Rising drug resistance is a matter of concern.
伤寒和非伤寒沙门氏菌血流感染的临床和微生物学特征:来自一所大学医院的观察研究
摘要背景 沙门氏菌的种类分布和耐药性模式随时间和地点的不同而不同。快速正确使用抗生素需要了解抗生素的分布和耐药性模式。因此,我们旨在研究患者的临床特征以及血液中沙门氏菌分离株的形态和抗体谱。材料和方法 这是一项观察性研究,于2019年12月至2021年12月在我们大学医院进行。血液培养物通过自动血液培养系统进行处理。沙门氏菌分离株通过形态特征、生化反应和血清学试验进行鉴定。通过Kirby–Bauer椎间盘扩散法和Phoenix自动化系统评估抗生素敏感性模式。后果 研究中患者的男女比例为2.5:1,患者的平均年龄为11.7岁(1-27岁)。从1350例阳性血液培养物中分离出21例沙门氏菌。9个分离株被鉴定为伤寒杆菌,7个被鉴定为霍乱杆菌,3个被鉴定成副伤寒杆菌A,2个被鉴定出副伤寒杆菌B。免疫受损条件与非伤寒沙门氏菌菌血症显著相关(p = 0.0253)。分离株对萘啶酸的耐药性最高(100%),其次是氟喹诺酮类(52.4%)。多药耐药性、极端耐药性和阿奇霉素耐药性分别为14.3%、4.8%和4.8%。观察到20名患者治疗后的恢复情况。结论 霍乱链球菌在沙门氏菌中的出现在血流感染中,仅次于伤寒杆菌。耐药性的上升令人担忧。
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来源期刊
Journal of Laboratory Physicians
Journal of Laboratory Physicians MEDICINE, GENERAL & INTERNAL-
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发文量
99
审稿时长
31 weeks
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