Clinical and Immunological Efficacy of an Eucalyptus Leaf Preparation in Chronic Periodontitis Treatment: A Randomized Interventional Longitudinal Clinical Study

A. Zub, T. Gayvoronskaya, A. Muratova, A. Arutyunov
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引用次数: 0

Abstract

Background. The prevalence of inflammatory-destructive periodontal diseases remains to be a global problem. Long-term topical application of chlorhexidine bigluconate and metronidazole is known to involve various side effects, thereby requiring widening the spectrum of herbal preparations used for treating chronic periodontitis.Aim. To evaluate the efficacy of Chlorophyllipt in the treatment of chronic generalized periodontitis by studying cytokine concentration dynamics in the gingival fluid.Methods. A randomized controlled clinical study of outcomes achieved in 50 patients with chronic generalized periodontitis treated in Dental Polyclinic No. 3, Krasnodar Кrai, was carried out. The control group included 20 clinically healthy people. Patients diagnosed with chronic generalized periodontitis were divided into the main (n = 25) and comparison (n = 25) groups. The main group received basic therapy and conventional conservative treatment with the addition of Chlorophyllipt. The comparison group received basic therapy and conventional conservative treatment. The therapy efficacy was estimated based on clinical indicators and IL-1β, IL-1Ra, IL-8, and TNF-α cytokine levels in the gingival fluid before treatment and after 14 days, three days, and six months of treatment. Statistical analysis was performed using the SPSS version 15 software (USA).Results. All clinical parameters improved significantly in both chronic periodontitis groups after 14 days, three days, and six months of treatment in comparison with their levels before treatment (p < 0.001). At the same time, the conventional conservative treatment with the addition of Chlorophyllipt reduced inflammatory processes in periodontal tissues and gum bleeding at earlier stages. In the main group IL-1β, cytokine levels after 14 days of treatment were 19% lower than in the comparison group (p = 0.025), while IL-1Ra cytokine levels were 52% higher (p = 0.023). Six months after treatment, IL-1β and TNF-α cytokine levels were 14% and 32% lower than in the control group, respectively (p2 = 0.021 and p2 = 0.008), while IL-1Ra cytokine levels were 39% higher (p =0.019). All these results were statistically significant.Conclusion. Due to the established clinical and immunological efficacy, Chlorophyllipt can   be included in the conventional conservative therapy of chronic generalized periodontitis. The determined levels of IL-1β, IL-1Ra, and TNF-α cytokines in chronic periodontitis patients can be used when assessing the response of periodontal tissues towards therapeutic interventions.
桉树叶制剂治疗慢性牙周炎的临床和免疫学疗效:一项随机干预的纵向临床研究
背景炎性破坏性牙周病的流行仍然是一个全球性问题。众所周知,双葡糖酸氯己定和甲硝唑的长期局部应用会产生各种副作用,因此需要扩大用于治疗慢性牙周炎的草药制剂的范围。目标通过研究龈液中细胞因子浓度动态,评价叶绿素治疗慢性全身性牙周炎的疗效。方法。对克拉斯诺达尔Кrai 3号牙科综合诊所治疗的50名慢性全身性牙周炎患者的疗效进行了随机对照临床研究。对照组包括20名临床健康人。诊断为慢性全身性牙周炎的患者被分为主要组(n=25)和对照组(n=25%)。主要组接受基础治疗和常规保守治疗,并加用叶绿素。对照组接受基础治疗和常规保守治疗。根据治疗前和治疗14天、3天和6个月后牙龈液中的临床指标和IL-1β、IL-1Ra、IL-8和TNF-α细胞因子水平来评估治疗效果。使用SPSS 15版软件(美国)进行统计分析。后果与治疗前相比,两组慢性牙周炎患者在治疗14天、3天和6个月后的所有临床参数均显著改善(p<0.001)。同时,添加叶绿素的传统保守治疗减少了早期牙周组织的炎症过程和牙龈出血。主组IL-1β治疗14天后细胞因子水平比对照组低19%(p=0.025),IL-1Ra细胞因子水平高52%(p=0.023)。治疗6个月后,IL-1β和TNF-α细胞因子水平分别比对照组降低14%和32%(p2=0.021和p2=0.008),IL-1Ra细胞因子水平升高39%(p=0.019)。所有这些结果都具有统计学意义。结论由于已确立的临床和免疫疗效,叶绿素ipt可纳入慢性全身性牙周炎的常规保守治疗。慢性牙周炎患者IL-1β、IL-1Ra和TNF-α细胞因子的测定水平可用于评估牙周组织对治疗干预的反应。
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