A Decenary Update on Metal Oxide Nanoparticles as a Heterogeneous Greener Catalyst for the Synthesis of Bioactive Heterocycles

IF 0.9 Q4 CHEMISTRY, PHYSICAL

Current Organocatalysis Pub Date : 2023-04-26 DOI:10.2174/2213337210666230426161057

Kantharaju Kamanna, Krishnappa B Badiger

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Abstract

In recent years, heterocycle derivatives have emerged as promising molecules, and have exhibited remarkable pharmacological applications. The statistical data analysis of the presently available drug molecules in the market has revealed that more than 70% of the drug candidates are derived from the heterocycles. Various synthetic protocols have been established employing a wide range of catalysts and reaction conditions; among them, one of the catalytic areas includes nanomaterials of metals and metal oxides. Nanocatalysts play an important role in the organic transformation under green chemistry protocol, due to their recycling nature and provision of the required catalytic amount. In this review, we have provided a comprehensive summary of the recent progress made in the catalytic heterogeneous metal oxide NPs application, exclusively for the synthesis of heterocyclic compounds reported in the period from 2012 to 2021. Also, this review provides an inherent framework for the reader to select a suitable catalytic system of interest to synthesize desired oxygen, nitrogen, and sulphur heteroatoms containing heterocyclic scaffold with potential pharmacological activit

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金属氧化物纳米颗粒作为合成生物活性杂环的非均相绿色催化剂的研究进展

近年来，杂环衍生物已成为一种很有前途的分子，并在药理学上有着显著的应用。对市场上现有药物分子的统计数据分析表明，70%以上的候选药物来自杂环。采用广泛的催化剂和反应条件已经建立了各种合成方案；其中，催化领域包括金属纳米材料和金属氧化物。纳米催化剂由于其回收性质和所需催化量的提供，在绿色化学协议下的有机转化中发挥着重要作用。在这篇综述中，我们全面总结了2012年至2021年期间报道的催化非均相金属氧化物纳米粒子在杂环化合物合成中的应用进展。此外，这篇综述为读者选择合适的催化体系来合成所需的含氧、氮和硫杂原子的杂环支架提供了一个内在的框架，该杂环支架具有潜在的药理学活性

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来源期刊

Current Organocatalysis CHEMISTRY, PHYSICAL-

CiteScore

2.00

自引率

0.00%

发文量

期刊介绍： Current Organocatalysis is an international peer-reviewed journal that publishes significant research in all areas of organocatalysis. The journal covers organo homogeneous/heterogeneous catalysis, innovative mechanistic studies and kinetics of organocatalytic processes focusing on practical, theoretical and computational aspects. It also includes potential applications of organocatalysts in the fields of drug discovery, synthesis of novel molecules, synthetic method development, green chemistry and chemoenzymatic reactions. This journal also accepts papers on methods, reagents, and mechanism of a synthetic process and technology pertaining to chemistry. Moreover, this journal features full-length/mini review articles within organocatalysis and synthetic chemistry. It is the premier source of organocatalysis and synthetic methods related information for chemists, biologists and engineers pursuing research in industry and academia.