Regenerative effect of epiregulin-loaded hydrogel

Q1 Medicine
Mario Migliario, Filippo Renò
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引用次数: 0

Abstract

Rapid and efficient wound healing response is essential to maintain whole organism integrity and homeostasis. Such process could be influenced by a plethora of factors that when interfering with the different healing phases finally result in impaired tissue repair. Furthermore, defective healing process is often associated with chronic and difficult to heal wounds, both conditions deeply affecting patients’ quality of life.

Advanced wound management solutions are the new standard in difficult to heal treatment and their key feature is represented by their ability to protect the wound bed but also to direct cellular behavior.

The aim of the present work was to evaluate the effectiveness of a bioactive hydrogel in modulating wound healing in a rat excisional wound model.

Surgical wounds were treated with hydrogel matrix enriched with a keratinocyte specific growth factor (epiregulin), saline (control condition) or the different hydrogel components alone.

Results showed from both a macroscopic and microscopic point of view a faster wound closure in hydrogel treated wounds associated with a better quality of the regenerated tissue.

Such results thus support the use of the proposed hydrogel matrix as a springboard to develop innovative advanced wound dressings to treat difficult to heal wounds.

表调节蛋白负载水凝胶的再生效果
快速有效的伤口愈合反应对维持整个机体的完整性和稳态至关重要。这一过程可能受到过多因素的影响,当干扰不同的愈合阶段时,最终导致组织修复受损。此外,愈合过程的缺陷通常与慢性和难以愈合的伤口有关,这两种情况都会严重影响患者的生活质量。先进的伤口管理解决方案是难以愈合治疗的新标准,其主要特点是能够保护伤口床,同时也能指导细胞行为。本研究的目的是评估生物活性水凝胶在大鼠切除伤口模型中调节伤口愈合的有效性。手术伤口用富含角质细胞特异性生长因子(表调节素)、生理盐水(对照条件)或不同水凝胶成分的水凝胶基质处理。结果显示,从宏观和微观的角度来看,水凝胶治疗的伤口愈合速度更快,再生组织质量更好。因此,这些结果支持使用所提出的水凝胶基质作为跳板,开发创新的先进伤口敷料来治疗难以愈合的伤口。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Wound Medicine
Wound Medicine Medicine-Surgery
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