Repetitive transcranial magnetic stimulation in patients with late life depression influences phenylalanine metabolism

IF 0.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Pteridines Pub Date : 2018-07-01 DOI:10.1515/PTERIDINES-2018-0008

F. Leblhuber, K. Steiner, J. Gostner, D. Fuchs

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引用次数: 6

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is used to treat different neuropsychiatric conditions like Parkinson’s disease, essential tremor, stroke, cognitive decline, dementia and depression. rTMS may exert its therapeutic effects by influencing the biochemistry of neurotransmitters. In this exploratory study, safety symptom improvement and changes in the availability of neurotransmitter precursor amino acids were studied following prefrontal cortex (PFC) stimulation using repetitive transcranial stimulation with TheraCell apparatus R (Guth Meditec, Salach, Germany) as an additional treatment in ten patients with late life depression. Treatment was well tolerated with no serious adverse effects being observed. rTMS induced a significant improvement in the symptoms of depression and a significant decrease in the HAMD-7 (p <0.03). At the same time, the serum phenylalanine to tyrosine ratio declined significantly (p <0.04). No significant influence of rTMS on tryptophan breakdown and serum neopterin concentrations was observed. These preliminary findings indicate that rTMS may influence the activity of the enzyme phenylalanine hydroxylase (PAH) which plays a key role in the biosynthesis of neurotransmitter precursors related to neuropsychiatric symptoms in late life depression. However, results were obtained from only 10 patients. Larger studies are therefore required to support these conclusions

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反复经颅磁刺激对晚期抑郁症患者苯丙氨酸代谢的影响

重复经颅磁刺激（rTMS）用于治疗不同的神经精神疾病，如帕金森病、原发性震颤、中风、认知能力下降、痴呆和抑郁症。rTMS可能通过影响神经递质的生物化学来发挥其治疗作用。在这项探索性研究中，研究了10名晚期抑郁症患者在前额叶皮层（PFC）刺激后的安全性症状改善和神经递质前体氨基酸可用性的变化，该刺激使用TheraCell设备R（Guth Meditec，Salach，Germany）进行重复经颅刺激作为额外治疗。治疗耐受性良好，未观察到严重不良反应。rTMS可显著改善抑郁症状，显著降低HAMD-7（p＜0.03）。同时，血清苯丙氨酸与酪氨酸的比值显著下降（p＜0.04）。rTMS对色氨酸分解和血清新蝶呤浓度没有显著影响。这些初步发现表明，rTMS可能影响苯丙氨酸羟化酶（PAH）的活性，PAH在与晚期抑郁症神经精神症状相关的神经递质前体的生物合成中起着关键作用。然而，结果仅来自10名患者。因此，需要进行更大规模的研究来支持这些结论

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pteridines 生物-生化与分子生物学

CiteScore

1.20

自引率

25.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.