A Sub-Nanostructural Transformable Nanozyme for Tumor Photocatalytic Therapy

IF 31.6 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Nano-Micro Letters Pub Date : 2022-04-12 DOI:10.1007/s40820-022-00848-y

Xi Hu, Nan Wang, Xia Guo, Zeyu Liang, Heng Sun, Hongwei Liao, Fan Xia, Yunan Guan, Jiyoung Lee, Daishun Ling, Fangyuan Li

{"title":"A Sub-Nanostructural Transformable Nanozyme for Tumor Photocatalytic Therapy","authors":"Xi Hu, Nan Wang, Xia Guo, Zeyu Liang, Heng Sun, Hongwei Liao, Fan Xia, Yunan Guan, Jiyoung Lee, Daishun Ling, Fangyuan Li","doi":"10.1007/s40820-022-00848-y","DOIUrl":null,"url":null,"abstract":"<div><h2>Highlights</h2><div>\n \n \n <ul>\n <li>\n <p>An internal sub-nanostructural transformation of sub-nanostructural transformable gold@ceria (STGC-PEG) is initiated by the conversion between CeO<sub>2</sub> and electron-rich state of CeO<sub>2−x</sub>, and active oxygen vacancies generation via the hot-electron injection from gold to ceria.</p>\n </li>\n <li>\n <p>The sub-nanostructural transformation of STGC-PEG enhances the peroxidase-like activity and activates the plasmon-promoted oxidase-like activity, resulting in an augmented reactive oxygen species output.</p>\n </li>\n <li>\n <p>STGC-PEG successfully achieves excellent low power (50 mW cm<sup>−2</sup>) near-infrared light-activated photocatalytic ablation of tumors in vivo.</p>\n </li>\n </ul>\n \n </div></div>","PeriodicalId":48779,"journal":{"name":"Nano-Micro Letters","volume":null,"pages":null},"PeriodicalIF":31.6000,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40820-022-00848-y.pdf","citationCount":"18","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano-Micro Letters","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s40820-022-00848-y","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 18

Abstract

Highlights

An internal sub-nanostructural transformation of sub-nanostructural transformable gold@ceria (STGC-PEG) is initiated by the conversion between CeO₂ and electron-rich state of CeO_2−x, and active oxygen vacancies generation via the hot-electron injection from gold to ceria.
The sub-nanostructural transformation of STGC-PEG enhances the peroxidase-like activity and activates the plasmon-promoted oxidase-like activity, resulting in an augmented reactive oxygen species output.
STGC-PEG successfully achieves excellent low power (50 mW cm⁻²) near-infrared light-activated photocatalytic ablation of tumors in vivo.

查看原文本刊更多论文

用于肿瘤光催化治疗的亚纳米结构可转化纳米酶

亚纳米结构可转换材料gold@ceria (STGC-PEG)的内部亚纳米结构转变是由CeO2向富电子态CeO2−x的转化以及金向铈的热电子注入生成活性氧空位引发的。STGC-PEG的亚纳米结构转化增强了过氧化物酶样活性，并激活了等离子体促进的氧化酶样活性，从而增加了活性氧的输出。STGC-PEG在体内成功实现了低功率(50 mW cm−2)近红外光激活的肿瘤光催化消融。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nano-Micro Letters NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

42.40

自引率

4.90%

发文量

715

审稿时长

13 weeks

期刊介绍： Nano-Micro Letters is a peer-reviewed, international, interdisciplinary and open-access journal that focus on science, experiments, engineering, technologies and applications of nano- or microscale structure and system in physics, chemistry, biology, material science, pharmacy and their expanding interfaces with at least one dimension ranging from a few sub-nanometers to a few hundreds of micrometers. Especially, emphasize the bottom-up approach in the length scale from nano to micro since the key for nanotechnology to reach industrial applications is to assemble, to modify, and to control nanostructure in micro scale. The aim is to provide a publishing platform crossing the boundaries, from nano to micro, and from science to technologies.