Neurotoxic effects of γ-aminobutyric acid A receptor and its signal pathways and general anesthetics on developmental neurons

国际麻醉学与复苏杂志 Pub Date : 2020-01-15 DOI:10.3760/CMA.J.ISSN.1673-4378.2020.01.025

Ya-jun Bai

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Abstract

With the development of surgical technology, more and more infants and pregnant women require surgery under general anesthesia. The neurotoxic effects of general anesthetics on late pregnancy and the development of infants and babies and related mechanisms have always been a hot topic. The excitotoxicity of γ-aminobutyric acid A (GABAA) receptor is one of the possible mechanisms involved in the neurotoxic effects of general anesthetics on developmental neurons. This review is designed to investigate the possible mechanism of GABAA receptor and its signaling pathways in the neurotoxic effects of general anesthetics on developmental neurons. Meanwhile, in-depth study and understanding of the relationship between GABAA receptor and its upstream and downstream signal pathways, especially the with-no-lysine (WNKs)-SPS1-related proline/alanine-rich kinase (SPAK)/oxidative stress-responsive 1 protein (OSR1) signal pathway, and the neurotoxic effects of general anesthetics on developmental neurons is done, so as to provide new ideas and targets for reducing the neurotoxicity of general anesthetics in the future. Key words: General anesthetics; Developmental phase; Neuron; Neurotoxicity; γ-aminobutyric acid A receptor; With-no-lysine-SPS1-related proline/alanine-rich kinase/oxidative stress-responsive 1 protein signal pathway

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γ-氨基丁酸A受体及其信号通路与全麻对发育神经元的神经毒性作用

随着外科技术的发展，越来越多的婴儿和孕妇需要在全身麻醉下进行手术。全身麻醉药对妊娠晚期和婴儿发育的神经毒性作用及其相关机制一直是人们关注的热点。γ-氨基丁酸A（GABAA）受体的兴奋性毒性是全身麻醉药对发育神经元的神经毒性作用的可能机制之一。本综述旨在探讨GABAA受体及其信号通路在全身麻醉药对发育神经元的神经毒性作用中的可能机制。同时，深入研究和了解GABAA受体及其上下游信号通路，特别是无赖氨酸（WNKs）-SPS1相关的脯氨酸/富丙氨酸激酶（SPAK）/氧化应激反应蛋白1（OSR1）信号通路的关系，以及全身麻醉药对发育神经元的神经毒性作用，为今后降低全身麻醉药的神经毒性提供新的思路和靶点。关键词：全身麻醉药；发育阶段；神经元；神经毒性；γ-氨基丁酸A受体；与赖氨酸-SPS1相关的脯氨酸/富含丙氨酸的激酶/氧化应激反应1蛋白信号通路

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国际麻醉学与复苏杂志

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