Ionic liquid mediated and promoted one-pot green synthesis of new isoxazolyl dihydro-1H-indol-4(5H)-one derivatives at ambient temperature

Abstract

Abstract We report a mild, inexpensive, fast, highly efficient, and eco-friendly protocol for the synthesis of new isoxazolyl dihydro-1H-indol-4(5H)-ones by a catalyst-free, one-pot three-component reaction of 4-amino-3-methyl-5-styrylisoxazoles, dimedone, and 2-chloroacetophenones under 1-methyl imidazolium tetraflouroborate ([HMIm]BF4) as task-specific ionic liquid at room temperature. The important aspects of the present methodology are: use of green solvent, short reaction time, catalyst free, compatibility with wide range of substrates, ease of recovery, reusability of reaction medium, and good yields.