MDR1 Gene Polymorphism and Phenytoin Pharmacokinetics in Epilepsy

Abstract

29 Epilepsy is considered one of the major public health problems and could have serious psychological and physical consequences, including mental health disorders, traumatic injury and premature death1. Epilepsy is a chronic and disabling neurologic disorder and affects approximately 1% of the population globally, especially in developing countries1,2. Although good prognosis has been seen in most patients with epilepsy, approximately 20% to 30% of patients with epilepsy do not remain seizure free despite the intervention of multiple antiepileptic drugs (AEDs)3,4,5.