Progress of long non-coding RNA HOTAIR in leukemia

Abstract

Long non-coding RNA (lncRNA) is a kind of regulatory RNA molecules with a length of more than 200nt, which can be involved in epigenetic modification of cells and gene expression by altering the chromatin status. HOTAIR is a kind of lncRNA, and some researches have found that HOTAIR may involved in the occurrence and development of leukemia, and it is obviously related to the diagnosis, treatment and prognosis of leukemia. This review summarizes the discovery, function, detection methods of HOTAIR and the latest research progress in leukemia, to provide new ideas for the diagnosis, individualized treatment and prognosis of leukemia. Key words: Leukemia; Long non-coding RNA; Diagnosis; HOTAIR; Prognosis