Progress of long non-coding RNA HOTAIR in leukemia

Q4 Medicine

肿瘤研究与临床 Pub Date : 2019-12-28 DOI:10.3760/CMA.J.ISSN.1006-9801.2019.12.017

Chen Wang

引用次数: 0

Abstract

Long non-coding RNA (lncRNA) is a kind of regulatory RNA molecules with a length of more than 200nt, which can be involved in epigenetic modification of cells and gene expression by altering the chromatin status. HOTAIR is a kind of lncRNA, and some researches have found that HOTAIR may involved in the occurrence and development of leukemia, and it is obviously related to the diagnosis, treatment and prognosis of leukemia. This review summarizes the discovery, function, detection methods of HOTAIR and the latest research progress in leukemia, to provide new ideas for the diagnosis, individualized treatment and prognosis of leukemia. Key words: Leukemia; Long non-coding RNA; Diagnosis; HOTAIR; Prognosis

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长链非编码RNA HOTAIR在白血病中的研究进展

长非编码RNA（lncRNA）是一种长度超过200nt的调节性RNA分子，可通过改变染色质状态参与细胞的表观遗传学修饰和基因表达。HOTAIR是一种lncRNA，一些研究发现HOTAIR可能参与白血病的发生和发展，并与白血病的诊断、治疗和预后明显相关。本文综述了HOTAIR的发现、功能、检测方法以及白血病的最新研究进展，为白血病的诊断、个体化治疗和预后提供新的思路。关键词：白血病；长非编码RNA；诊断；热空气；预后

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍： "Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association. It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.