Central Compartment Involvement in T3 & T4 Papillary Thyroid Carcinoma

IF 0.1 Q4 OTORHINOLARYNGOLOGY

Bangladesh Journal of Otorhinolaryngology Pub Date : 2023-03-02 DOI:10.3329/bjo.v28i2.64298

Md Murshedur Rahman, B. Siddiquee, Hawlader Mohammad Mustafizur Rahman, Mohammad Habibur Rahaman, Md. Lutfor Rahaman, Sabyasachi Talukdar

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Abstract

Background: Lymphatic metastasis in papillary thyroid cancer (PTC) is common; however, the extent of central compartment lymph nodes dissection (CCD) is controversial and requires the knowledge of pattern for central compartment (level VI) lymph nodes metastasis (CCM). Objective: To determine the frequency of central compartment (level VI) lymph node metastasis in T3 & T4 papillary thyroid carcinoma. Methods: This study was conducted in the Department of Otolaryngology-Head &Neck Surgery, BSMMU, Dhaka, from January 2019 to June 2020. A total of 31 cases of T3 & T4 PTC were selected after obtaining clearance and approval from the IRB of BSMMU; the subjects were included based on the inclusion and exclusion criteria. After taking informed written consent detailed history and examination was done. Ultrasound neck and fine-needle aspiration cytology was taken from all thyroid swelling. All patients had underwent total thyroidectomy with central compartment dissection. The data were analyzed by computer-based statistical software SPSS version 26. Results were expressed as frequency and percentage. Z proportion test was done as applicable. Results: In this study, mean (±SD) tumor size was 3.66 (±1.34) cm. 20 (64.52%) had T3 and 11 (35.48%) T4 PTC. 11 (35.48%) had N0, 20 (64.52%) N1a and 8 (25.81%) N1b. 20 (64.52%) had overall central compartment lymph nodes metastasis. Among T3 papillary thyroid carcinoma, 12 (60%) had overall central compartment lymph nodes metastasis, and inT4 papillary thyroid carcinoma, 8 (72.7%) had overall central compartment lymph nodes metastasis. This difference was not statistically significant. Conclusion: The frequency of central compartment (level VI) lymph node metastasis (CCM) is high (64.52%) in T3 & T4 papillary thyroid carcinoma. So central compartment (level VI) should be dissected in advanced (T3 & T4) papillary thyroid carcinoma. Bangladesh J Otorhinolaryngol 2022; 28(2): 149-156

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T3和T4甲状腺乳头状癌的中心区室受累

背景：癌症（PTC）的淋巴结转移是常见的；然而，中央隔室淋巴结清扫（CCD）的范围是有争议的，并且需要了解中央隔室（VI级）淋巴结转移（CCM）的模式。目的：探讨T3、T4甲状腺乳头状癌中心区（VI级）淋巴结转移的发生率。方法：本研究于2019年1月至2020年6月在达卡BSMMU耳鼻咽喉头颈外科进行。在获得BSMMU IRB的批准和批准后，共选择了31例T3和T4 PTC；根据纳入和排除标准纳入受试者。在取得知情同意书后，进行详细的病史和检查。对所有甲状腺肿胀进行超声颈部和细针抽吸细胞学检查。所有患者均接受了甲状腺全切除术，并进行了中央室分离。数据采用SPSS 26版计算机统计软件进行分析。结果用频率和百分比表示。在适用的情况下进行Z比例测试。结果：在本研究中，平均（±SD）肿瘤大小为3.66（±1.34）cm。20例（64.52%）有T3和11例（35.48%）有T4 PTC。其中N0 11例（35.48%），N1a 20例（64.52%），N1b 8例（25.81%）。20例（64.52%）有中央淋巴结转移。在T3甲状腺乳头状癌中，有12例（60%）发生了全部中央室淋巴结转移，在T4甲状腺乳头状瘤中，有8例（72.7%）发生了整体中央室淋巴淋巴结转移。这种差异在统计学上并不显著。结论：T3、T4甲状腺乳头状癌中心区（VI级）淋巴结转移发生率高（64.52%）。因此，在晚期（T3和T4）甲状腺乳头状癌中，应解剖中心区室（VI级）。孟加拉国耳鼻喉科杂志2022；28（2）：149-156

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Bangladesh Journal of Otorhinolaryngology OTORHINOLARYNGOLOGY-

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