MR spectroscopy in Alzheimer’s disease

IF 0.3 Q4 SPECTROSCOPY

Biomedical Spectroscopy and Imaging Pub Date : 2020-05-15 DOI:10.3233/bsi-200194

N. Sheikh-Bahaei

引用次数: 5

Abstract

MR Spectroscopy (MRS) has been used for diagnosis of many neurological disorders such as central nervous system tumors and neuro-inflammatory diseases. Despite many studies on MRS in neurodegenerative disorders and particularly Alzheimer’s disease, its utility has been hampered by lack of standard techniques across studies and limited data on the association between the level of metabolites in MRS and pathological changes of AD. In this review we have summarized the findings of MRS in Alzheimer’s disease, discussed the limitation of the current data and the pitfalls in interpretation of the MRS results and also we presented the latest developments in this field and potential future steps in order to utilize MRS more effectively in clinical practice.

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阿尔茨海默病的磁共振光谱

MR波谱（MRS）已被用于诊断许多神经系统疾病，如中枢神经系统肿瘤和神经炎症性疾病。尽管对MRS在神经退行性疾病，特别是阿尔茨海默病中的作用进行了许多研究，但由于研究中缺乏标准技术，以及MRS中代谢物水平与阿尔茨海默病病理变化之间关系的数据有限，它的实用性受到了阻碍，讨论了当前数据的局限性和MRS结果解释中的陷阱，我们还介绍了该领域的最新发展和未来的潜在步骤，以便在临床实践中更有效地利用MRS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomedical Spectroscopy and Imaging SPECTROSCOPY-

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期刊介绍： Biomedical Spectroscopy and Imaging (BSI) is a multidisciplinary journal devoted to the timely publication of basic and applied research that uses spectroscopic and imaging techniques in different areas of life science including biology, biochemistry, biotechnology, bionanotechnology, environmental science, food science, pharmaceutical science, physiology and medicine. Scientists are encouraged to submit their work for publication in the form of original articles, brief communications, rapid communications, reviews and mini-reviews. Techniques covered include, but are not limited, to the following: • Vibrational Spectroscopy (Infrared, Raman, Teraherz) • Circular Dichroism Spectroscopy • Magnetic Resonance Spectroscopy (NMR, ESR) • UV-vis Spectroscopy • Mössbauer Spectroscopy • X-ray Spectroscopy (Absorption, Emission, Photoelectron, Fluorescence) • Neutron Spectroscopy • Mass Spectroscopy • Fluorescence Spectroscopy • X-ray and Neutron Scattering • Differential Scanning Calorimetry • Atomic Force Microscopy • Surface Plasmon Resonance • Magnetic Resonance Imaging • X-ray Imaging • Electron Imaging • Neutron Imaging • Raman Imaging • Infrared Imaging • Terahertz Imaging • Fluorescence Imaging • Near-infrared spectroscopy.