Model‐based diagnosis with FTTell: Diagnosing early pediatric failure to thrive

IF 1.6 3区工程技术 Q4 ENGINEERING, INDUSTRIAL

Systems Engineering Pub Date : 2023-03-29 DOI:10.1002/sys.21674

N. Soskin, Fatma Yasin, D. Dori, R. Shaoul

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引用次数: 0

Abstract

Pediatric Failure To Thrive (FTT), commonly presented in young infants, is often not diagnosed on time or missed. Lack of timely infants’ diagnosis can adversely affect their growth and development. We have developed and successfully tested FTTell—a model‐based system for diagnosing FTT during common pediatric follow up. FTTell is an executable model‐based diagnostic tool for diagnosing FTT. We use Object‐Process Methodology extended with Methodical Approach to Executable Integrative Modeling, enabling qualitative considerations and quantitative parameters of the problem to be modeled jointly, enabling FTT diagnosis. The validity of FTTell is demonstrated on data collected from 100 infants. For each child, FTTell calculates a score indicating FTT presence and severity. We compared the systems’ outcomes to a pediatric gastroenterologist expert severity assessment. Of the 100 infants, the system initially yielded 82% validity. Reassessment improved it to 87% validity. Pediatricians may miss infants with FTT, especially in borderline cases. FTTell can effectively serve as a FTT diagnosis tool, boosting pediatricians’ correct diagnosis and proper investigation. Our cloud‐based system can be continuously updated with the latest research findings. FTTell can diagnose FTT and its severity in infants with 87% accuracy. Pediatricians can use this model‐based standardized approach to improve their FTT diagnosis and provide appropriate timely intervention when needed. Model‐based diagnosis is a novel application of conceptual models, and OPM ISO 19450 is especially fit for this purpose. The model‐based diagnosis approach can be extended beyond medicine to diagnosing problems with engineered, technological, and socio‐technical systems.

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基于模型的FTTell诊断：诊断早期儿童发育不良

儿童发育迟缓（FTT）通常发生在年幼的婴儿身上，通常没有及时诊断或错过。缺乏及时的婴儿诊断可能会对他们的生长发育产生不利影响。我们已经开发并成功测试了FTTell——一种基于模型的系统，用于在常见的儿科随访中诊断FTT。FTTell是一个可执行的基于模型的诊断工具，用于诊断FTT。我们使用对象-过程方法论扩展了可执行集成建模的方法论，使问题的定性考虑和定量参数能够联合建模，从而实现FTT诊断。FTTell的有效性是通过从100名婴儿身上收集的数据来证明的。对于每个孩子，FTTell计算一个分数，指示FTT的存在和严重程度。我们将该系统的结果与儿科胃肠病专家的严重程度评估进行了比较。在100名婴儿中，该系统最初产生了82%的有效性。重新评估将其有效性提高到87%。儿科医生可能会错过患有FTT的婴儿，尤其是在临界病例中。FTTell可以有效地作为FTT诊断工具，促进儿科医生的正确诊断和适当调查。我们基于云的系统可以不断更新最新的研究结果。FTTell可以诊断婴儿FTT及其严重程度，准确率为87%。儿科医生可以使用这种基于模型的标准化方法来改进他们的FTT诊断，并在需要时提供适当的及时干预。基于模型的诊断是概念模型的一种新应用，OPM ISO 19450特别适合这一目的。基于模型的诊断方法可以从医学扩展到工程、技术和社会技术系统的诊断问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Systems Engineering 工程技术-工程：工业

CiteScore

5.10

自引率

20.00%

发文量

审稿时长

6 months

期刊介绍： Systems Engineering is a discipline whose responsibility it is to create and operate technologically enabled systems that satisfy stakeholder needs throughout their life cycle. Systems engineers reduce ambiguity by clearly defining stakeholder needs and customer requirements, they focus creativity by developing a system’s architecture and design and they manage the system’s complexity over time. Considerations taken into account by systems engineers include, among others, quality, cost and schedule, risk and opportunity under uncertainty, manufacturing and realization, performance and safety during operations, training and support, as well as disposal and recycling at the end of life. The journal welcomes original submissions in the field of Systems Engineering as defined above, but also encourages contributions that take an even broader perspective including the design and operation of systems-of-systems, the application of Systems Engineering to enterprises and complex socio-technical systems, the identification, selection and development of systems engineers as well as the evolution of systems and systems-of-systems over their entire lifecycle. Systems Engineering integrates all the disciplines and specialty groups into a coordinated team effort forming a structured development process that proceeds from concept to realization to operation. Increasingly important topics in Systems Engineering include the role of executable languages and models of systems, the concurrent use of physical and virtual prototyping, as well as the deployment of agile processes. Systems Engineering considers both the business and the technical needs of all stakeholders with the goal of providing a quality product that meets the user needs. Systems Engineering may be applied not only to products and services in the private sector but also to public infrastructures and socio-technical systems whose precise boundaries are often challenging to define.