Magnetically triggered release of biologics

IF 16.8 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

International Materials Reviews Pub Date : 2019-02-17 DOI:10.1080/09506608.2018.1446280

Olivia L. Lanier, Adam G Monsalve, P. McFetridge, J. Dobson

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引用次数: 15

Abstract

ABSTRACT The development of platforms for the controlled release of therapeutic molecules remains a crucial research focus, as controlled release reduces the frequency of administration, minimizes side effects and improves compliance. However, biological conditions and diseases with a progression that exhibits strong temporal dependence, or those that can result in the evolution of tolerance to the therapeutic during continuous exposure, require the development of sophisticated release systems tailored to the needs to the individual and the disease. Thus, there has been emphasis on the development of platforms with remotely controlled release mechanisms. Specifically, magnetically triggered release utilizes magnetic nanoparticles as the remote control modality. Many reviews discuss the magnetically triggered release of small molecule drugs, however, the release of biomacromolecules has not been reviewed. This review examines the limited work on the magnetically triggered release of biomacromolecules and the challenges associated with their delivery. Important material parameters that have been used in this pursuit are discussed.

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磁力触发生物制剂的释放

摘要治疗分子控释平台的开发仍然是一个重要的研究重点，因为控释降低了给药频率，最大限度地减少了副作用，并提高了依从性。然而，生物条件和疾病的进展表现出强烈的时间依赖性，或者那些可能导致在持续暴露期间对治疗药物产生耐受性的疾病，需要开发适合个人和疾病需求的复杂释放系统。因此，一直强调开发具有远程控制释放机制的平台。具体而言，磁触发释放利用磁性纳米颗粒作为远程控制模式。许多综述讨论了小分子药物的磁触发释放，然而，生物大分子的释放尚未得到综述。这篇综述考察了磁性触发生物大分子释放的有限工作以及与释放相关的挑战。讨论了在本研究中使用的重要材料参数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Materials Reviews 工程技术-材料科学：综合

CiteScore

28.50

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： International Materials Reviews (IMR) is a comprehensive publication that provides in-depth coverage of the current state and advancements in various materials technologies. With contributions from internationally respected experts, IMR offers a thorough analysis of the subject matter. It undergoes rigorous evaluation by committees in the United States and United Kingdom for ensuring the highest quality of content. Published by Sage on behalf of ASM International and the Institute of Materials, Minerals and Mining (UK), IMR is a valuable resource for professionals in the field. It is available online through Sage's platform, facilitating convenient access to its wealth of information. Jointly produced by ASM International and the Institute of Materials, Minerals and Mining (UK), IMR focuses on technologies that impact industries dealing with metals, structural ceramics, composite materials, and electronic materials. Its coverage spans from practical applications to theoretical and practical aspects of material extraction, production, fabrication, properties, and behavior.