Image characteristics and quantitative analysis of multicolor imaging in eyes with cystoid macular edema

Q4 Medicine

中华眼底病杂志 Pub Date : 2020-01-25 DOI:10.3760/CMA.J.ISSN.1005-1015.2020.01.006

Lu He, Changzheng Chen, Zuohuizi Yi, Xiaoling Wang, A’min Xu

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引用次数: 0

Abstract

Objective To observe the imaging features of cystoid macular edema (CME) in multicolor imaging (MC), and to evaluate the value of MC in the diagnosis of CME. Methods Descriptive case series study. From August 2017 to June 2018, 42 eyes of 37 patients with CME diagnosed in the people's Hospital of Wuhan University were included in the study. Among them, there were 24 males and 13 females, with an average age of 48.51±10.29 years. There were 14 eyes with diabetic retinopathy, 14 eyes with central retinal vein occlusion, 8 eyes with branch retinal vein occlusion, 4 eyes with uveitis, and 2 eyes with Eales disease. The macular color fundus photography (CFP) was performed with Visucam 200 non-mydriatic fundus camera of Zeiss company in Germany. MC, frequnce domainoptical OCT (SD-OCT) and FFA were examined by Spectralis HRA2 + OCT of Heidelberg company in Germany. According to the MC standard method, five images, including 488 nm blue reflection (BR), 515 nm green reflection (GR), 820 nm infrared reflection (IR) imaging and standard MC and blue-green enhancement (BG), were obtained at the same time. Compared with SD-OCT, CFP and MC images were scored. Friedman M test and Wilcoxon signed rank test were used for statistical analysis. Results The standard MC and BG images showed blue-green uplift area or petal-shaped appearance, surrounded by green reflection areas with clear boundaries. BR image can be seen in the low reflexes area. On the GR image, there were patches or cystic low reflection areas, surrounded by a slightly high reflection. On the IR image, patches or cystoid high reflexes can be seen, surrounded by low reflection dark areas with clear boundaries. The average scores of CFP, standard MC, GB, IR, GR and BR were 1.20±0.94, 3.05±0.99, 2.90±1.04, 2.55±1.27, 2.00±0.94, 0.51±0.85 respectively, and the differences were statistically significant (χ2= 151.61, P=0.000). The score of CFP were significantly lower than that of standard MC (Z=-5.421), BG (Z=-5.354), IR (Z=-4.714), GR (Z=-4.438) and higher than that of BR (Z=-3.435). The differences were statistically significant (P=0.000, 0.000, 0.000, 0.000, 0.001). Conclusions The quality of MC imaging is better than that of CFP. Combined with SD-OCT, it can be used as an assistant method to diagnose CME. Key words: Macular edema/diagnosis; Tomographyoptical coherence; Fluorescein angiography; Multicolor imaging

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黄斑囊样水肿多色影像特征及定量分析

目的观察囊样黄斑水肿(CME)的多色影像特征，探讨多色影像对CME的诊断价值。方法描述性病例系列研究。2017年8月至2018年6月，在武汉大学人民医院确诊的CME患者37例，42只眼纳入研究。其中男性24例，女性13例，平均年龄48.51±10.29岁。糖尿病视网膜病变14眼，视网膜中央静脉阻塞14眼，视网膜分支静脉阻塞8眼，葡萄膜炎4眼，Eales病2眼。采用德国蔡司公司Visucam 200型无散光眼底相机进行黄斑彩色眼底摄影(CFP)。MC、频率域光学OCT (SD-OCT)和FFA采用德国海德堡公司Spectralis HRA2 + OCT检测。根据MC标准方法，同时获得488 nm蓝色反射(BR)、515 nm绿色反射(GR)、820 nm红外反射(IR)成像和标准MC和蓝绿色增强(BG) 5幅图像。与SD-OCT比较，对CFP和MC图像进行评分。采用Friedman M检验和Wilcoxon符号秩检验进行统计分析。结果标准MC和BG图像呈蓝绿色隆起区或花瓣状，周围有边界清晰的绿色反射区。低反射区可见BR图像。GR图像上可见斑块状或囊状低反射区，周围为微高反射区。红外图像上可见高反射斑块或囊状，周围为边界清晰的低反射暗区。CFP、标准MC、GB、IR、GR、BR平均得分分别为1.20±0.94、3.05±0.99、2.90±1.04、2.55±1.27、2.00±0.94、0.51±0.85，差异均有统计学意义(χ2= 151.61, P=0.000)。CFP评分显著低于标准MC (Z=-5.421)、BG (Z=-5.354)、IR (Z=-4.714)、GR (Z=-4.438)，高于BR (Z=-3.435)。差异有统计学意义(P=0.000, 0.000, 0.000, 0.000, 0.001)。结论MC显像质量优于CFP。结合SD-OCT可作为诊断CME的辅助方法。关键词:黄斑水肿/诊断;Tomographyoptical一致性;荧光素血管造影;多色成像

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来源期刊

中华眼底病杂志 Medicine-Ophthalmology

CiteScore

0.40

自引率

0.00%

发文量

5383

期刊介绍： Chinese Journal of Ocular Fundus Diseases is the only scientific journal in my country that focuses on reporting fundus diseases. Its purpose is to combine clinical and basic research, and to give equal importance to improvement and popularization. It comprehensively reflects the leading clinical and basic research results of fundus disease disciplines in my country; cultivates professional talents in fundus disease, promotes the development of fundus disease disciplines in my country; and promotes academic exchanges on fundus disease at home and abroad. The coverage includes clinical and basic research results of posterior segment diseases such as retina, uveal tract, vitreous body, visual pathway, and internal eye diseases related to systemic diseases. The readers are medical workers and researchers related to clinical and basic research of fundus diseases. According to the journal retrieval report of the Chinese Institute of Scientific and Technological Information, the comprehensive ranking impact factor and total citation frequency of the Chinese Journal of Ocular Fundus Diseases have been among the best in the disciplines of ophthalmology, otolaryngology, and ophthalmology in my country for many years. The papers published have been included in many important databases at home and abroad, such as Scopus, Peking University Core, and China Science Citation Database (CSCD).