Analysis results of prognostic factors affecting survival outcome for locoregional recurrence in postmastectomy of breast cancer

Abstract

Objective To investigate the prognostic factors affecting survival outcome for locoregional recurrence in postmastectomy of breast cancer. Methods A retrospective study was performed on 61 breast cancer patients who suffering outcome of locoregional recurrence(LRR)treated by modified radical mastectomy.The clinical data of LRR patients with breast cancer and distant metastasis and clinical pathologic factors of survival were analyzed. Results Univariate analysis showed that triple-negative breast cancer, HER2-enriched breast cancer, time to LRR less than 2 years, no surgical removal of the lesions of LRR were correlated to survival outcome for LRR in postmastectomy of breast cancer.Multivariate analysis revealed that triple-negative breast cancer, HER2-enriched breast cancer, no surgical removal of the lesions of LRR were independent risk factors influencing risk of distant metastasis for LRR in postmastectomy of breast cancer.Among them, the risks of distant metastasis of triple-negative breast cancer, HER2-enriched breast cancer after LRR are 3.58 times and 2.87 times more than Luminal A/B(HER2-negative)breast cancer.In addition, triple-negative breast cancer, HER2-enriched breast cancer were independent risk factors influencing overall survival after LRR, their risk of death were 3.886 times and 3.097 times more than Luminal A/B(HER2-negative)breast cancer. Conclusion LRR of breast cancer after mastectomy correlates with a high risk of distant metastasis events and death in particular in patients with triple-negative and HER2-enriched breast cancer.Radiotherapy and mastectomy for LRR are warranted to reduce the risk of distant metastasis. Key words: Triple-negative breast cancer; HER2-enriched breast cancer; Locoregional recurrence; Modified radical mastectomy; Breast cancer