Self-Assembly Study of Sodium Salt of 2-Amidodecyl Pyridine-5-Boronic Acid and Sodium Salt of 2-Amidododecyl Pyridine-5-Boronic Acid in Buffer Solution

Abstract

Boronic acid based amphiphiles are new generation green surfactant materials because they degrade to produce environmentally friendly boric acid. This study describes the interfacial property as well as aggregation behaviour of two pyridine based boronic acid amphiphiles containing amide linkage in hydrocarbon chain named sodium salt of 2-amidodecyl pyridine-5-boronic acid (SADPB) and sodium salt of 2-amidododecyl pyridine-5-boronic acid (SADDPB). Tensiometry study was executed for investigation of interfacial properties of pyiridine based boronic acid derivatives. Polarity and viscosity of the microenvironment of aggregates was investigated using fluorescence technique. DLS measurement suggested size of the assemblies of SADDPB is larger than SADPB in solutions. XRD technique was employed to examine arrangement of the hydrophobic tails in the bilayer aggregates. TEM technique was utilised to scrutinize aggregate morphology in solutions. The findings showed prospect of these amphiphiles to be applicable as drug carrier in pharmaceutical industries.