Healthy Aging Guided by Circadian Rhythm Monitoring Using a Smartwatch-Like Device

IF 0.4 Q4 NEUROSCIENCES

Archives of Neuroscience Pub Date : 2021-07-31 DOI:10.5812/ans.108154

A. B. Nogueira, M. J. Teixeira

{"title":"Healthy Aging Guided by Circadian Rhythm Monitoring Using a Smartwatch-Like Device","authors":"A. B. Nogueira, M. J. Teixeira","doi":"10.5812/ans.108154","DOIUrl":null,"url":null,"abstract":": Aging is the main factor for onset of disease. Nonetheless, chronological age does not necessarily correspond to biological age. The regulation of aging, circadian rhythms, and temperature involves the same brain structure: the hypothalamus. We previously showed that the analysis of the circadian rhythm of temperature may predict neurologic signs with 24 hours of antecedence. Our hypothesis is that the circadian rhythm of temperature changes gradually with aging and correlates with biological age. This study aims to assess whether the circadian rhythm of temperature correlates with the chronological age of healthy individuals aged between 18 and 72 years and changes more intensely in individuals with obesity, which is a disease associated with unhealthy aging. To achieve the study goals, 60 individuals will be enrolled and separated into four groups according to age (< or ≥ 45 years) and health status (healthy or obese). The participants will wear a wristband with vital sign sensors and an accelerometer for three days to detect movement during wake period and lack of movement during sleep period. The ratio between the mean skin temperature during the sleep and preceding wake period will be the main parameter to be analyzed in the study. The possible result is that this ratio is higher in healthy young individuals, as well as healthy age-matched individuals. This could imply the discovery of a simple and non-invasive method related to the biological age that could guide the prevention and treatment of aging-related diseases.","PeriodicalId":43970,"journal":{"name":"Archives of Neuroscience","volume":" ","pages":""},"PeriodicalIF":0.4000,"publicationDate":"2021-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5812/ans.108154","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 1

Abstract

: Aging is the main factor for onset of disease. Nonetheless, chronological age does not necessarily correspond to biological age. The regulation of aging, circadian rhythms, and temperature involves the same brain structure: the hypothalamus. We previously showed that the analysis of the circadian rhythm of temperature may predict neurologic signs with 24 hours of antecedence. Our hypothesis is that the circadian rhythm of temperature changes gradually with aging and correlates with biological age. This study aims to assess whether the circadian rhythm of temperature correlates with the chronological age of healthy individuals aged between 18 and 72 years and changes more intensely in individuals with obesity, which is a disease associated with unhealthy aging. To achieve the study goals, 60 individuals will be enrolled and separated into four groups according to age (< or ≥ 45 years) and health status (healthy or obese). The participants will wear a wristband with vital sign sensors and an accelerometer for three days to detect movement during wake period and lack of movement during sleep period. The ratio between the mean skin temperature during the sleep and preceding wake period will be the main parameter to be analyzed in the study. The possible result is that this ratio is higher in healthy young individuals, as well as healthy age-matched individuals. This could imply the discovery of a simple and non-invasive method related to the biological age that could guide the prevention and treatment of aging-related diseases.

查看原文本刊更多论文

使用类似智能手表的设备监测昼夜节律，引导健康衰老

：衰老是发病的主要因素。尽管如此，按时间顺序排列的年龄并不一定与生物年龄相对应。衰老、昼夜节律和温度的调节涉及相同的大脑结构：下丘脑。我们之前表明，对温度昼夜节律的分析可以预测提前24小时的神经系统症状。我们的假设是，温度的昼夜节律随着年龄的增长而逐渐变化，并与生物年龄相关。这项研究旨在评估温度的昼夜节律是否与年龄在18岁至72岁之间的健康人的实际年龄相关，以及肥胖者的昼夜节律变化是否更强烈，肥胖是一种与不健康衰老相关的疾病。为了实现研究目标，将60名患者纳入研究，并根据年龄（＜或≥45岁）和健康状况（健康或肥胖）分为四组。参与者将佩戴带有生命体征传感器和加速度计的腕带三天，以检测清醒期的运动和睡眠期的运动不足。睡眠期间的平均皮肤温度和前一次觉醒期间的平均温度之间的比率将是研究中要分析的主要参数。可能的结果是，这一比例在健康的年轻人以及年龄匹配的健康人中更高。这可能意味着发现了一种与生物年龄相关的简单且无创的方法，可以指导衰老相关疾病的预防和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Archives of Neuroscience NEUROSCIENCES-

自引率

0.00%

发文量

期刊介绍： Archives of neuroscience is a clinical and basic journal which is informative to all practitioners like Neurosurgeons, Neurologists, Psychiatrists, Neuroscientists. It is the official journal of Brain and Spinal Injury Research Center. The Major theme of this journal is to follow the path of scientific collaboration, spontaneity, and goodwill for the future, by providing up-to-date knowledge for the readers. The journal aims at covering different fields, as the name implies, ranging from research in basic and clinical sciences to core topics such as patient care, education, procuring and correct utilization of resources and bringing to limelight the cherished goals of the institute in providing a standard care for the physically disabled patients. This quarterly journal offers a venue for our researchers and scientists to vent their innovative and constructive research works. The scope of the journal is as far wide as the universe as being declared by the name of the journal, but our aim is to pursue our sacred goals in providing a panacea for the intractable ailments, which leave a psychological element in the daily life of such patients. This authoritative clinical and basic journal was founded by Professor Madjid Samii in 2012.