THE CORRELATION BETWEEN L-CARNITINE UPTAKE AND SOME HEMATOLOGICAL PARAMETERS IN OXIDATIVE STRESSED RATS

Abstract

The objective of this research was to determine the effect of L-carnitine antioxidant ability on some hematological parameters such as the extent of red blood corpuscles (RBCs), "Packed cells volume (PCV)", Hemoglobin (Hb), and Mean cellular volume (MCV) in normal and oxidative stress exposed rats respectively. Using an animal model, "Hydrogen peroxide ((H2O2 0.5 %)" was mixed with drinking tap water to induce oxidative stress through the experiment period (30 days). Three groups were used in this study (each containing 7 rats) one of them was the negative control group and the other two were the positive control group (oxidative stress group treated with H2O2) and the treatment group treated with H2O2 + L-carnitine. The oxidative stress group showed a significant decrease (P<0.05) in RBCs count, and no significant differences (P<0.05) were observed in Hb, PCV, and MCV compared with the control group on the other hand the treatment group revealed a significant increase (P<0.05) in RBCs count in cooperation with the oxidative stress group. It can be concluded that L-carnitine has a positive key role toward H2O2 induced oxidative stress. This role positively affects the red bone marrow and erythropoiesis through balancing the negative effect of oxidative stress and can be monitored through RBCs count only.