Biosensors for waterborne virus detection: Challenges and strategies

IF 6.1 1区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Pharmaceutical Analysis Pub Date : 2023-11-01 DOI:10.1016/j.jpha.2023.08.020

Xixi Song, Zina Fredj, Yuqiao Zheng, Hongyong Zhang, Guoguang Rong, Sumin Bian, Mohamad Sawan

{"title":"Biosensors for waterborne virus detection: Challenges and strategies","authors":"Xixi Song, Zina Fredj, Yuqiao Zheng, Hongyong Zhang, Guoguang Rong, Sumin Bian, Mohamad Sawan","doi":"10.1016/j.jpha.2023.08.020","DOIUrl":null,"url":null,"abstract":"<div><p>Waterborne viruses that can be harmful to human health pose significant challenges globally, affecting health care systems and the economy. Identifying these waterborne pathogens is essential for preventing diseases and protecting public health. However, handling complex samples such as human and wastewater can be challenging due to their dynamic and complex composition and the ultralow concentration of target analytes. This review presents a comprehensive overview of the latest breakthroughs in waterborne virus biosensors. It begins by highlighting several promising strategies that enhance the sensing performance of optical and electrochemical biosensors in human samples. These strategies include optimizing bioreceptor selection, transduction elements, signal amplification, and integrated sensing systems. Furthermore, the insights gained from biosensing waterborne viruses in human samples are applied to improve biosensing in wastewater, with a particular focus on sampling and sample pretreatment due to the dispersion characteristics of waterborne viruses in wastewater. This review suggests that implementing a comprehensive system that integrates the entire waterborne virus detection process with high-accuracy analysis could enhance virus monitoring. These findings provide valuable insights for improving the effectiveness of waterborne virus detection, which could have significant implications for public health and environmental management.</p></div>","PeriodicalId":16737,"journal":{"name":"Journal of Pharmaceutical Analysis","volume":"13 11","pages":"Pages 1252-1268"},"PeriodicalIF":6.1000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2095177923002095/pdfft?md5=f154207aa61bcaf9953cdad76608b13f&pid=1-s2.0-S2095177923002095-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical Analysis","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2095177923002095","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

Abstract

Waterborne viruses that can be harmful to human health pose significant challenges globally, affecting health care systems and the economy. Identifying these waterborne pathogens is essential for preventing diseases and protecting public health. However, handling complex samples such as human and wastewater can be challenging due to their dynamic and complex composition and the ultralow concentration of target analytes. This review presents a comprehensive overview of the latest breakthroughs in waterborne virus biosensors. It begins by highlighting several promising strategies that enhance the sensing performance of optical and electrochemical biosensors in human samples. These strategies include optimizing bioreceptor selection, transduction elements, signal amplification, and integrated sensing systems. Furthermore, the insights gained from biosensing waterborne viruses in human samples are applied to improve biosensing in wastewater, with a particular focus on sampling and sample pretreatment due to the dispersion characteristics of waterborne viruses in wastewater. This review suggests that implementing a comprehensive system that integrates the entire waterborne virus detection process with high-accuracy analysis could enhance virus monitoring. These findings provide valuable insights for improving the effectiveness of waterborne virus detection, which could have significant implications for public health and environmental management.

Abstract Image

查看原文本刊更多论文

用于水传播病毒检测的生物传感器:挑战和策略

对人类健康有害的水传播病毒给全球带来了重大挑战，影响着医疗保健系统和经济。识别这些水传播病原体对于预防疾病和保护公众健康至关重要。然而，由于人类和废水等复杂样本的动态复杂成分以及目标分析物的超低浓度，处理这些样本可能具有挑战性。本综述全面概述了水传播病毒生物传感器的最新突破。文章首先强调了几种可提高人体样本中光学和电化学生物传感器传感性能的可行策略。这些策略包括优化生物受体选择、传导元件、信号放大和集成传感系统。此外，从人体样本中的水传播病毒生物传感中获得的启示也被应用于改进废水中的生物传感，由于废水中的水传播病毒具有分散特性，因此重点关注取样和样本预处理。这篇综述表明，实施一个将整个水传播病毒检测过程与高精度分析相结合的综合系统，可以加强病毒监测。这些发现为提高水传播病毒检测的有效性提供了宝贵的见解，对公共卫生和环境管理具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Pharmaceutical Analysis Chemistry-Electrochemistry

CiteScore

16.20

自引率

2.30%

发文量

674

审稿时长

22 weeks

期刊介绍： The Journal of Pharmaceutical Analysis (JPA), established in 2011, serves as the official publication of Xi'an Jiaotong University. JPA is a monthly, peer-reviewed, open-access journal dedicated to disseminating noteworthy original research articles, review papers, short communications, news, research highlights, and editorials in the realm of Pharmacy Analysis. Encompassing a wide spectrum of topics, including Pharmaceutical Analysis, Analytical Techniques and Methods, Pharmacology, Metabolism, Drug Delivery, Cellular Imaging & Analysis, Natural Products, and Biosensing, JPA provides a comprehensive platform for scholarly discourse and innovation in the field.