Effects of renal Na-Cl co-transporter on calcium homeostasis and bone metabolism

Abstract

Osteoporosis is a global public health problem. The kidney, especially the Na-Cl co-transporter (NCC) located in the renal distal tubular cells, which is an important transporter for urinary calcium regulation, plays an important role in calcium homeostasis and bone metabolism. This review summarized recent researches on effects and mechanisms of NCC on calcium and bone metabolism. Key words: Na-Cl co-transporter; Calcium homeostasis; Bone metabolism