Three cases of phosphine poisoning misdiagnosed as fluoroacetamide poisoning and literature review

Yujuan Wang, Youpeng Jin, C. Zhao, Zhengyun Sun, Wei Wang
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引用次数: 0

Abstract

目的 探讨儿童磷化氢中毒的临床特点及诊疗,进一步减少该病的误诊、漏诊率及病死率。 方法 总结2018年我院小儿重症医学科收治的误诊为氟乙酰胺中毒的磷化氢中毒病例3例,对3例患儿的临床特点、治疗情况及预后进行总结分析。 结果 3例患儿均以恶心、呕吐起病,以神经系统及心血管系统损害为主,误诊为氟乙酰胺中毒。后经详细追问病史,确诊为磷化氢中毒。经过血液净化、维生素C、甲泼尼龙、磷酸肌酸以及必要的呼吸循环支持等治疗后,2例痊愈出院,1例临床死亡。 结论 急性磷化氢中毒病死率高,对于婴幼儿,当家长提供磷化铝或磷化锌等毒物接触史或可疑接触史时,要注意是否发生磷化氢中毒,并尽早给予血液净化治疗,为救治患儿争取时间,改善预后。
膦中毒误诊为氟乙酰胺中毒3例并文献复习
Objective: To explore the clinical characteristics and diagnosis and treatment of phosphine poisoning in children, and further reduce the misdiagnosis, missed diagnosis rate, and mortality rate of the disease. Method: Three cases of phosphine poisoning misdiagnosed as fluoroacetamide poisoning admitted to the pediatric intensive care department of our hospital in 2018 were summarized and analyzed for their clinical characteristics, treatment status, and prognosis. The results showed that all 3 patients developed nausea and vomiting, with neurological and cardiovascular system damage being the main symptoms. They were misdiagnosed as fluoroacetamide poisoning. After detailed investigation of the medical history, it was diagnosed as phosphine poisoning. After treatment with blood purification, vitamin C, methylprednisolone, creatine phosphate, and necessary respiratory and circulatory support, 2 cases recovered and were discharged, while 1 case died clinically. Conclusion: Acute phosphine poisoning has a high mortality rate. For infants and young children, when parents provide a history of exposure to toxic substances such as aluminum phosphide or zinc phosphide or a suspected history of exposure, attention should be paid to whether phosphine poisoning has occurred, and blood purification treatment should be given as soon as possible to buy time for treating the child and improve prognosis.
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期刊介绍: Chinese Journal of Neurology was established in 1955, the predecessor of which is Chinese Journal of Neurology and Psychiatry. Chinese Journal of Neurology and Psychiatry has been indexed by MEDLINE until 1996, when it was divided into two journals, Chinese Journal of Neurology, and Chinese Journal of Psychiatry. Chinese Journal of Neurology is now indexed by EM, SCOPUS, AJ, WPRIM, CNKI, Wanfang Data, CSCD, etc. The impact factor of the journal is 2.755 in 2017, ranking the first among all neurological and psychological journals in China and among all the 142 medical journals published by the Chinese Medical Association. The journal is available both in print and online.
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