Assessment of Tpe/QT Ratio, Tpe/QTc Ratio, and Tpe Interval in Patients with an Ulcerative Colitis

Abstract

Objective: In this study, our aim was to investigate the change in Tpe/QTc, Tpe/QT ratios, and Tpe interval in patients with ulcerative colitis (UC). Methods: Our cross-sectional study included 40-patients followed-up with a UC diagnosis and 40 healthy controls. All the patients underwent 12-lead electrocardiography (ECG). In addition to the routine ECG measurements, Tpe/QT and Tpe/QTc ratios and Tpe interval were measured. Resting heart rate and serum high-sensitive C-reactive protein (hs-CRP) levels were higher with UC patients (p<0.05). Tpe interval and Tpe/QTc ratio values were higher in patients with UC (p<0.05). QT and QTc measurements were similar in the UC patients and healthy controls. Ratio of Tpe to QT and QTc, and Tpe distance measurements positively correlated with the heart rate, UC disease duration, and hs-CRP (p<0.05 for each-one). Tpe/QT, Tpe/QTc ratios, and Tpe interval were found to be independently associated with the heart rate and UC disease duration in a linear regression analyze. Conclusion: In patients with UC; Tpe/QT, Tpe/QTc ratios, and Tpe interval are increased and are independently associated with a disease duration in these patients. This may be associated with the increased inflammation in the UC patients and its cardiac effects. lead electrocardiographic (ECG) changes with a serious ventricular ECG are interval and T wave-peak and (Tpe