PCL Based CIP-Loaded Double-Layer Films Deposited by Low-Electron Beam Dispersion Method and its Antibacterial Properties

IF 0.5 Q4 CHEMISTRY, MULTIDISCIPLINARY

Eurasian Chemico-Technological Journal Pub Date : 2020-12-28 DOI:10.18321/ectj997

Qin Xu, Beibei Li, Xu Zhengwei, Xiaohong Jiang, M. Yarmolenko, A. Rogachev, A. Rogachev

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Abstract

In this paper, low-electron beam dispersion (EBD) method is used to prepare a kind of double-layer films on different substrates. The bottom layer is a mechanically stirred mixture of the degradable polycaprolactone (PCL) and ciprofloxacin (CIP), and the top layer is polyurethane (PU) film. The molecular structure, chemical composition and morphology of the double-layer films were investigated by FTIR, XPS and SEM. The results showed that the surfaces of the double-layer films are uniform and the thicknesses can reach micron level. In addition, the two layers are well bonded. Then the films were sliced and immersed in PBS solution, and the time-dependent variable was used to analyze the kinetic slow-release behavior of CIP in the double-layer films by agar diffusion antibacterial experiments. It can be seen that sustained release time of CIP in the double-layer films can be up to 7 days, which is due to fact that the upper PU film working as a sealing layer helps to realize the drug slow-release. Based on the above research, the comprehensive performance of the films with the composition of PCL:CIP/PU=1:1/1 is the best.

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低电子束分散法制备PCL基CIP负载双层膜及其抗菌性能

本文采用低电子束色散(EBD)方法在不同的衬底上制备了一种双层薄膜。底层是可降解聚己内酯(PCL)和环丙沙星(CIP)的机械搅拌混合物，顶层是聚氨酯(PU)薄膜。利用FTIR、XPS和SEM对双层膜的分子结构、化学成分和形貌进行了表征。结果表明，双层膜表面均匀，膜厚可达微米级。此外，两层结合良好。然后将膜切片并浸泡在PBS溶液中，通过琼脂扩散抗菌实验分析双层膜中CIP的动力学缓释行为。可以看出，CIP在双层膜中的缓释时间可达7天，这是由于上层PU膜作为密封层，有助于实现药物的缓释。综合以上研究，PCL:CIP/PU=1:1/1的组合膜综合性能最好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eurasian Chemico-Technological Journal CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.10

自引率

20.00%

发文量

审稿时长

20 weeks

期刊介绍： The journal is designed for publication of experimental and theoretical investigation results in the field of chemistry and chemical technology. Among priority fields that emphasized by chemical science are as follows: advanced materials and chemical technologies, current issues of organic synthesis and chemistry of natural compounds, physical chemistry, chemical physics, electro-photo-radiative-plasma chemistry, colloids, nanotechnologies, catalysis and surface-active materials, polymers, biochemistry.