Late Impact of COVID-19 Pneumonia on Testosterone Levels in Recovered, Post-Hospitalized Male Patients

IF 0.6 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Endocrinology and Metabolism Pub Date : 2021-07-25 DOI:10.14740/jem749

M. Aboelnaga, A. Abdelrazek, N. Abdullah, M. El Shaer

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引用次数: 4

Abstract

Background: Recent studies reported lower androgen levels in coronavirus disease 2019 (COVID-19) hospitalized patients which linked to a worse prognosis. However, these studies were conducted in patients with active disease and long-term consequences are still not yet known. Therefore, we aimed to evaluate the late impact of COVID-19 pneumonia on testosterone levels in late recovered, post-hospitalized males. Methods: We enrolled 55 COVID-19 pneumonia-recovered, post-hospitalized male patients after an average of 60 days of discharge from the hospital and 40 age, body mass index (BMI), and waist-matched participants enrolled in this case-control study. The total testosterone cut-off point was set as 300 ng/dL and the cut-off point for luteinizing hormone (LH) was set as 9.4 IU/L. Results: Testosterone deficiency prevalence was 50.9%, and testosterone deficiency was mainly hypogonadotropic (60.7%). Late recovered COVID-19 pneumonia patients had significantly lower total testosterone and calculated free testosterone and higher testosterone to LH ratio and prevalence of testosterone deficiency in comparison with the control group. Testosterone-deficient COVID-19 pneumonia patients had significantly higher anthropometric parameters such as waist circumference and BMI, higher Charlson Comorbidity Index, and longer hospitalization time in comparison with testosterone-sufficient patients. Visceral obesity estimated with waist circumference was a significant predictor for total testosterone levels in COVID patients in regression analysis. Conclusion: Late recovered post-hospitalized COVID-19 pneumonia patients still have lower androgen levels and a higher prevalence of testosterone deficiency in comparison with matched control participants. Moreover, visceral obesity was the most significant predictor of low testosterone levels in recovered COVID-19 patients. J Endocrinol Metab. 2021;11(3-4):76-82 doi: https://doi.org/10.14740/jem749

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COVID-19肺炎对康复后住院男性患者睾酮水平的后期影响

背景：最近的研究报告称，2019冠状病毒病（新冠肺炎）住院患者的雄激素水平较低，这与更糟糕的预后有关。然而，这些研究是在活动性疾病患者中进行的，其长期后果尚不清楚。因此，我们旨在评估新冠肺炎肺炎对晚期康复、住院后男性睾酮水平的后期影响。方法：我们招募了55名新冠肺炎肺炎覆盖的住院后男性患者，他们平均出院60天，40岁，体重指数（BMI）和腰围匹配的参与者参加了这项病例对照研究。总睾酮的截止点设定为300ng/dL，促黄体生成素（LH）的截止点设为9.4IU/L。结果：睾酮缺乏症的患病率为50.9%，睾酮缺乏症主要为促性腺激素缺乏症（60.7%）。与对照组相比，晚期康复的新冠肺炎肺炎患者的总睾酮和计算的游离睾酮显著降低，睾酮与LH的比率和睾酮缺乏症患病率较高。与睾丸激素缺乏患者相比，睾丸激素缺乏型新冠肺炎肺炎患者的腰围和BMI等人体测量参数显著更高，Charlson合并症指数更高，住院时间更长。在回归分析中，用腰围估计内脏肥胖是新冠肺炎患者总睾酮水平的重要预测因素。结论：与匹配的对照组参与者相比，晚期康复的住院后新冠肺炎肺炎患者的雄激素水平仍较低，睾酮缺乏的患病率较高。此外，内脏肥胖是新冠肺炎康复患者睾丸激素水平低的最重要预测因素。内分泌代谢杂志。2021年；11（3-4）：76-82 doi:https://doi.org/10.14740/jem749

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来源期刊

Journal of Endocrinology and Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

0.70

自引率

0.00%

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