Analytical and toxicological aspects of dithiocarbamates: an overview of the last 10 years

IF 2.8 4区医学 Q2 TOXICOLOGY

Toxicology Mechanisms and Methods Pub Date : 2022-04-06 DOI:10.1080/15376516.2022.2063096

Jéssica Cristina Zoratto Romoli, Deborah Thais Palma Scanferla, Raul Gomes Aguera, Renata Sano Lini, G. C. Pante, C. B. Bueno Júnior, J. C. Castro, S. Mossini, C. Marchioni, M. M. Junior

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引用次数: 1

Abstract

Abstract Compilation studies related to toxicological aspects and also biological monitoring and analysis methods for specific fungicides and, mainly, those that belong to the class of the dithiocarbamates (DTCs) have not been carried out at least in the last ten years. DTCs – dimethyldithiocarbamates, ethylenebisditiocarbamates, propylenebisditiocarbamates – are organosulfur compounds that form complexes due to the presence of different chemical elements, which bind strongly and inhibit enzymes that are essential to the functioning of the organism, causing a serious proven adverse effect on biological systems, such as alteration of thyroid hormones, teratogenesis and neurotoxicity. It is still evident, as shown by world data, that the growing consumption of fungicides has increasingly exposed the population in general and, in particular, workers who deal with these substances. There is a scarcity of studies in the literature discussing the toxicological and analytical aspects that are important for understanding the real effects of DTCs and monitoring human exposure to them. Therefore, the aim of this work was to expose, in a comprehensive way and through a narrative review, gaps in research related to the fungicides of the DTCs class, their metabolites, as well as the toxicological and analytical aspects involved. The review is divided into two parts: (1) Toxicological aspects, including toxicokinetics, toxicodynamics and toxidromes; and (2) Analytical Toxicology, which comprises biomarkers, sample preparation and identification/quantification methods. Graphical Abstract

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二硫代氨基甲酸酯的分析和毒理学方面：过去10年综述

摘要至少在过去十年中，尚未对特定杀菌剂（主要是二硫代氨基甲酸酯类杀菌剂）的毒理学方面以及生物监测和分析方法进行汇编研究。DTC——二甲基二硫代氨基甲酸酯、亚乙基二硫代氨基乙酸酯、亚丙基二硫代氨基丁酸酯——是一种有机硫化合物，由于存在不同的化学元素而形成复合物，这些化学元素强烈结合并抑制对生物体功能至关重要的酶，对生物系统造成严重的不良影响，如甲状腺激素的改变，致畸性和神经毒性。正如世界数据所显示的那样，仍然很明显，杀菌剂的消费量不断增长，使普通人群，特别是处理这些物质的工人越来越暴露在外。文献中很少讨论毒理学和分析方面的研究，这些方面对了解DTC的真实影响和监测人类接触DTC的情况很重要。因此，这项工作的目的是通过叙述性综述，以全面的方式暴露与DTC类杀菌剂、其代谢物以及所涉及的毒理学和分析方面相关的研究空白。综述分为两部分：（1）毒理学方面，包括毒代动力学、毒代动力学和毒证；（2）分析毒理学，包括生物标志物、样品制备和鉴定/定量方法。图形摘要

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来源期刊

Toxicology Mechanisms and Methods TOXICOLOGY-

自引率

3.10%

发文量

期刊介绍： Toxicology Mechanisms and Methods is a peer-reviewed journal whose aim is twofold. Firstly, the journal contains original research on subjects dealing with the mechanisms by which foreign chemicals cause toxic tissue injury. Chemical substances of interest include industrial compounds, environmental pollutants, hazardous wastes, drugs, pesticides, and chemical warfare agents. The scope of the journal spans from molecular and cellular mechanisms of action to the consideration of mechanistic evidence in establishing regulatory policy. Secondly, the journal addresses aspects of the development, validation, and application of new and existing laboratory methods, techniques, and equipment. A variety of research methods are discussed, including: In vivo studies with standard and alternative species In vitro studies and alternative methodologies Molecular, biochemical, and cellular techniques Pharmacokinetics and pharmacodynamics Mathematical modeling and computer programs Forensic analyses Risk assessment Data collection and analysis.